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Omega-3 vetzuren voor gezonde ogen*
Uit een Franse laboratoriumstudie lijkt het dat omega-3 vetzuren schade aan het netvlies kunnen tegengaan.
Diabetici lopen op termijn door de hoge glucosewaarden een hoge kans op beschadiging van het netvlies, ook
diabetische retinopathie genoemd.
Retinopathie is de meest voorkomende oorzaak van blindheid. Uit de studie blijkt dat de omega-3 vetzuren
DHA en EPA de beschadigingen van het netvlies tegen kunnen gaan.
New approach to modulate retinal cellular toxic effects of high glucose using marine epa and dha
Mélody Dutot1*, Violaine de la Tourrette1, Roxane Fagon1 and Patrice Rat2
· * Corresponding author: Mélody Dutot melody.dutot@yslab.fr
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Nutrition & Metabolism 2011, 8:39 doi:10.1186/1743-7075-8-39
Abstract
Background
Protective effects of omega-3 fatty acids against cellular damages of high glucose were studied on retinal pigmented epithelial (RPE) cells.
Methods
Retinal epithelial cells were incubated with omega-3 marine oils rich in EPA and DHA and then with high glucose (25 mM) for 48 hours. Cellular responses were compared to normal glucose (5 mM): intracellular redox status, reactive oxygen species (ROS), mitochondrial succinate deshydrogenase activity, inflammatory cytokines release and caveolin-1 expression were evaluated using microplate cytometry, ELISA and flow cytometry techniques. Fatty acids incorporation in retinal cell membranes was analysed using chromatography.
Results
Preincubation of the cells with fish oil decreased ROS overproduction, mitochondrial alterations and TNFα release. These protective effects could be attributed to an increase in caveolin-1 expression induced by marine oil.
Conclusion
Marine formulations rich in omega-3 fatty acids represent a promising therapeutic approach for diabetic retinopathy.
De volledige studie.
(November 2011)
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