Volkoren voeding tegen hart- en vaatziektes*
Uit een kleine Schotse studie onder ruim 200 deelnemers blijkt dat dagelijkse maaltijden van
volkoren voeding zorgt voor een duidelijk lagere
bloeddruk, vergelijkbaar met de verlaging van de bloeddruk die medicijnen bereiken. 12 weken lang kregen de deelnemers maaltijden met volkoren granen als
tarwe en haver. Na afloop werden lagere bloeddrukken gemeten die de kans op een
hartaanval met 15% en de kans op een
beroerte met wel 25% doen verminderen.
Effect of increased consumption of whole-grain foods on blood pressure and other cardiovascular risk markers in healthy middle-aged persons: a randomized controlled trial1,2,3
1. Paula Tighe, 2. Garry Duthie, 3. Nicholas Vaughan, 4. Julie Brittenden,
5. William G Simpson, 6. Susan Duthie, 7. William Mutch, 8. Klaus Wahle,
9. Graham Horgan, and 10. Frank Thies
+ Author Affiliations
1. 1From the Division of Applied Medicine (PT, NV, JB, KW, and FT) and the Rowett Institute of Nutrition and Health (GD, SD, and FT), University of Aberdeen, Aberdeen, United Kingdom; Clinical Biochemistry, National Health Service Grampian, Aberdeen, United Kingdom (WGS and WM); and Biomathematics and Statistics Scotland, Aberdeen, United Kingdom (GH).
· ↵2 Supported by grant NO2035 from the Food Standard Agency and funding from the Scottish Government (Rural and Environment Research and Analysis Directorate; to GD and SD). Oat cakes were kindly provided by Paterson Arran Ltd, Livingston, United Kingdom.
· ↵3 Address reprint requests and correspondence to F Thies, Medical School, University of Aberdeen, Polwarth Building, Foresterhill, Aberdeen AB252ZD, United Kingdom. E-mail: f.thies@abdn.ac.uk.
Abstract
Background: Three daily portions of whole-grain foods could lower cardiovascular disease risk, but a comprehensive intervention trial was needed to confirm this recommendation.
Objectives: We aimed to assess the effects of consumption of 3 daily portions of whole-grain foods (provided as only wheat or a mixture of wheat and oats) on markers of cardiovascular disease risk in relatively high-risk individuals.
Design: This was a randomized controlled dietary trial in middle-aged healthy individuals. After a 4-wk run-in period with a refined diet, we randomly allocated volunteers to a control (refined diet), wheat, or wheat + oats group for 12 wk. The primary outcome was a reduction of cardiovascular disease risk factors by dietary intervention with whole grains, which included lipid and inflammatory marker concentrations, insulin sensitivity, and blood pressure.
Results: We recruited a total of 233 volunteers; 24 volunteers withdrew, and 3 volunteers were excluded. Systolic blood pressure and pulse pressure were significantly reduced by 6 and 3 mm Hg, respectively, in the whole-grain foods groups compared with the control group. Systemic markers of cardiovascular disease risk remained unchanged apart from cholesterol concentrations, which decreased slightly but significantly in the refined group.
Conclusions: Daily consumption of 3 portions of whole-grain foods can significantly reduce cardiovascular disease risk in middle-aged people mainly through blood pressure–lowering mechanisms. The observed decrease in systolic blood pressure could decrease the incidence of coronary artery disease and stroke by ≥15% and 25%, respectively. This trial was registered at clinicaltrials.gov as ISRCTN27657880.
(Maart 2011)
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