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Bewegen in combinatie met omega-3 vetzuren voor goede botten*
Uit een studie onder vrouwen in de leeftijd van 58-78 jaar blijkt dat het zowel bewegen als extra inname van omega-3 vetzuren tot de grotere botdichtheid leidt dan bewegen of inname van omega-3 vetzuren alleen. 24 weken lang kregen de deelnemers of alleen bewegen of alleen extra omega-3 vetzuren of beide of niets. Bewegen bestond uit drie keer in de week wandelen en joggen, extra omega-3 vetzuren was 1 gram/dag. Allerlei metingen werden verricht m.b.t. de botdichtheid en de verschillende markers voor bijv. ontstekingen. Alleen bewegen of alleen inname van omega-3 vetzuren bleken vergelijkbare goede resultaten te geven doch de combinatie van beide bleek veel betere resultaten te geven.
Long-term aerobic exercise and omega-3 supplementation modulate osteoporosis through inflammatory mechanisms in post-menopausal women: a randomized, repeated measures study
Bakhtyar Tartibian, Behzad Hajizadeh Maleki, Jill Kanaley and Karim Sadeghi
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Nutrition & Metabolism 2011, 8:71 doi:10.1186/1743-7075-8-71
Abstract (provisional)
Background
Evidence indicates that dietary fats and physical activity influence bone health. The purpose of this study was to examine the effects of long-term aerobic exercise and omega-3 (N-3) supplementation on serum inflammatory markers, bone mineral density (BMD), and bone biomarkers in post-menopausal women. 
Methods
Seventy-nine healthy sedentary post-menopausal women aged 58-78 years participated in this study. Subjects were randomized to one of 4 groups: exercise + supplement (E+S, n=21), exercise (E, n=20), supplement (S, n=20), and control (Con, n=18) groups. The subjects in the E+S and E groups performed aerobic exercise training (walking and jogging) up to 65% of HRmax, three times a week for 24 weeks. Subjects in the E+S and S groups consumed 1000 mg/d N-3 for 24 weeks. The lumbar spine (L2-L4) and femoral neck BMD, serum tumor necrosis factor (TNF) alpha, interleukin (IL) 6, prostaglandin (PG) E2, estrogen, osteocalcin, 1,25-dihydroxyvitamin D3 (1,25 Vit D), C-telopeptide (CTX), parathyroid hormone (PTH) and calcitonin (CT) were measured at baseline, the end of week 12 and 24. 
Results
Serum estrogen, osteocalcin, 1,25 Vit D, CT, L2-L4 and femoral neck BMD measures increased (P < 0.05) and the serum CTX, PTH, TNF-alpha, IL-6, and PGE2 decreased (P < 0.05) in E + S group after the 24 wk intervention but not in the E or S intervention groups. L2-L4 and femoral neck BMD, estrogen, osteocalcin, and CT were negatively (P < 0.05) correlated with TNF-alpha and PGE2. PTH and CT were correlated positively and negatively with IL-6, respectively (P < 0.05). 
Conclusions
The present study demonstrates that long-term aerobic exercise training plus N-3 supplementation have a synergistic effect in attenuating inflammation and augmenting BMD in post-menopausal osteoporosis. 
De volledige studie. (November 2011) 

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