Vitamine D en cirrose*
Uit een studie onder 123 personen met primaire biliaire cirrose of een door
alcohol veroorzaakte cirrose
blijkt dat deze patiënten meestal veel te lage bloedwaarden
vitamine D hebben. Bij de patiënten met de alcohol cirrose had 85%
bloedwaarden lager dan 20 ng/ml en zelfs 55% lager dan 10 ng/ml. Bij primaire
biliaire cirrose was resp. 60 en 16%. In beide groepen personen daalden de
bloedwaarden vitamine D met het erger worden van de ziekte.
Vitamin D Deficiency in Cirrhosis
Vitamin D deficiency is a well reported complication in chronic cholestatic liver disease such as primary biliary cirrhosis. While the prevalence and treatment of this deficiency has been addressed in many articles over the last decades, little is known of the vitamin D status in alcoholic liver cirrhosis.
A research article published in the World Journal of Gastroenterology addresses this question. The authors described the serum vitamin D status in a retrospective case series of patients with alcoholic liver cirrhosis compared to those with primary biliary cirrhosis.
The study showed that vitamin D deficiency is more frequent and severe in patients with alcoholic liver cirrhosis than in patients with primary biliary cirrhosis. Furthermore, it indicated that the degree of liver dysfunction, rather than the aetiology of cirrhosis, dictates the risk of vitamin D deficiency.
This study emphasizes the importance of monitoring vitamin D levels in all patients with cirrhosis. However, further studies are needed to find the most favourable form of vitamin D supplementation for these
patients. (Juli 2011)
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