Vitamine K tegen diabetes*
Uit een Nederlandse studie onder ruim 38.000 Nederlanders blijkt dat voldoende vitamine K
in de voeding belangrijk is voor een kleinere kans op diabetes
type-2. Zij met de meeste vitamine k in de voeding hebben wel 20% minder kans op de ziekte diabetes type-2. Zijn voor vitamine
K1 hoge inname's gewenst voor dit resultaat voor vitamine
K2 blijkt dat voor iedere 10 mcg per dag meer de kans wel 7% lager is.
Dietary Phylloquinone and Menaquinones Intakes and Risk of Type 2 Diabetes
1. Joline W.J. Beulens, PHD1,2,
2. Daphne L. van der A, PHD3,
3. Diederick E. Grobbee, MD1,
4. Ivonne Sluijs, MSC1,
5. Annemieke M.W. Spijkerman, PHD2 and
6. Yvonne T. van der Schouw, PHD1
+ Author Affiliations
1. 1Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands;
2. 2Center for Prevention and Health Services Research, National Institute for Public Health and the Environment, Bilthoven, the Netherlands;
3. 3Center for Nutrition and Health, National Institute for Public Health and the Environment, Bilthoven, the Netherlands.
1. Corresponding author: Joline Beulens, j.beulens@umcutrecht.nl.
Abstract
OBJECTIVE To investigate whether dietary phylloquinone and menaquinones intakes are related to risk of type 2 diabetes.
RESEARCH DESIGN AND METHODS We used data from a prospective cohort study in 38,094 Dutch men and women, aged 20-70 years. Dietary phylloquinone and menaquinones intakes were assessed using a validated food frequency questionnaire. Diabetes case patients were ascertained mainly via self-report and verified against medical records.
RESULTS During 10.3 years of follow-up, 918 incident cases of diabetes were documented. In a multivariate model adjusting for diabetes risk factors and dietary factors, phylloquinone intake tended to be associated (P = 0.08) with a reduced risk of type 2 diabetes with a hazard ratio (HR) of 0.81 (95% CI 0.66-0.99) for the highest versus the lowest quartile. For menaquinones intake, a linear, inverse association (P = 0.038) with risk of type 2 diabetes was observed with an HR of 0.93 (0.87-1.00) for each 10-µg increment in the multivariate model.
CONCLUSIONS This study shows that both phylloquinone and menaquinones intakes may be associated with a reduced risk of type 2 diabetes.
Het volledige artikel.
(Januari 2011)
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