Overgewicht, alcohol en roken verhogen nieuwe kans op kanker*
Uit een studie onder duizend patiënten met borstkanker blijkt dat overgewicht, het drinken van alcohol en roken de kans op
kanker in de andere borst flink doen toenemen. Alle patiënten hadden oestrogeen receptor-positieve borstkanker. Overgewicht
(BMI > 30) doet die kans met 40% stijgen t.o.v. vrouwen
met een BMI kleiner dan 26, meer dan 1 glas alcohol per dag geeft 90% meer kans
op weer kanker en blijven roken verhoogt die kans wel met 120%.
Obesity, Drinking, Smoking Contribute To Risk Of Second Breast Cancers
Obesity, smoking and alcohol use increase the risk that survivors of estrogen receptor-positive breast cancer will develop the disease in the other breast, according to a study published this week in the Journal of Clinical Oncology, Reuters reports. The study examined data on 365 women with a first estrogen receptor-positive breast cancer and a second cancer in the other breast, and 726 similar subjects without the second cancer.
According to the study, a cancer survivor with a body mass index greater than 30 is 40% more likely to develop cancer in the other breast than a woman with a BMI lower than 25. The study also found that drinking seven or more alcoholic beverages weekly was linked with a 90% increased chance of developing a second cancer, compared with drinking no alcohol. Current smoking was associated with a 120% increased chance of developing a second cancer, compared with never smoking, the study found.
Lead author Christopher Li of the Fred Hutchinson Cancer Research Center in Seattle said the study shows that women who maintain healthy weights, avoid smoking and drink in moderation can reduce their risk of developing second cancers. In an accompanying editorial, Jennifer Ligibel of the Dana-Farber Cancer Institute wrote that "randomized trials of weight loss and other behavioral interventions after breast cancer diagnosis (are) needed to determine whether changes in potentially modifiable risk factors in the years after breast cancer diagnosis could help lower the risk of second primary breast cancer and other adverse events in breast cancer survivors"
Results: Obesity, consumption of 7 alcoholic beverages per week, and current smoking were all positively related to risk of contralateral breast cancer (odds ratio [OR], 1.4; 95% CI, 1.0 to 2.1; OR, 1.9; 95% CI, 1.1 to 3.2; and OR, 2.2; 95% CI, 1.2 to 4.0, respectively). Compared with women who consumed fewer than 7 alcoholic beverages per week and were never or former smokers, women who consumed 7 drinks per week and were current smokers had a 7.2-fold (95% CI, 1.9 to 26.5) elevated risk of contralateral breast cancer.
Conclusion: Our population-based study adds to the limited available literature and suggests that obesity, smoking, and alcohol consumption influence contralateral breast cancer risk, affording breast cancer survivors three means of potentially reducing this risk.
(Oktober
2009)
