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Weiproteïnes tegen hoge bloeddruk*
Wei proteïnes blijken goed te zijn tegen hoge bloeddruk en voor verbetering van de wand van bloedvaten, zo blijkt uit een kleine studie onder 42 deelnemers. In de studie kregen de deelnemers 8 weken een van drie supplementen; wei proteïne, calcium caseïnaat of een placebo in de vorm van maltodextrine. 2x per dag 28 gram weiproteïne zorgde voor een duidelijk lagere bloeddruk, lager totaal cholesterol, lagere triglyceriden waarden en de vaatverwijdende eigenschappen bleken flink beter geworden te zijn.
De studie. (December 2016)

Whey protein lowers blood pressure and improves endothelial function and lipid biomarkers in adults with prehypertension and mild hypertension: results from the chronic Whey2Go randomized controlled trial1,2
1. Ágnes A Fekete3,4, Carlotta Giromini5, Yianna Chatzidiakou3, D Ian Givens4, and Julie A Lovegrove3,*
+ Author Affiliations
1. 3Hugh Sinclair Unit of Human Nutrition, Department of Food and Nutritional Sciences and Institute for Cardiovascular and Metabolic Research, School of Chemistry, Food and Pharmacy, and 
2. 4Food Production and Quality Research Division, School of Agriculture, Policy and Development, Faculty of Life Sciences, University of Reading, Reading, United Kingdom; and 
3. 5Department of Health, Animal Science and Food Safety, University of Milan, Milan, Italy 
+ Author Notes
· ↵1 Supported by the Biotechnology and Biological Sciences Research Council (United Kingdom) with collaboration from Volac International Ltd. This is an open access article distributed under the CC-BY license (http://creativecommons.org/licenses/by/3.0/). 
· ↵2 Supplemental Figures 1 and 2 and Supplemental Tables 1–3 are available from the “Online Supporting Material” link in the online posting of the article and from the same link in the online table of contents at http://ajcn.nutrition.org. 
1. ↵*To whom correspondence should be addressed. E-mail: j.a.lovegrove@reading.ac.uk. 
Abstract
Background: Cardiovascular diseases (CVDs) are the greatest cause of death globally, and their reduction is a key public-health target. High blood pressure (BP) affects 1 in 3 people in the United Kingdom, and previous studies have shown that milk consumption is associated with lower BP. 
Objective: We investigated whether intact milk proteins lower 24-h ambulatory blood pressure (AMBP) and other risk markers of CVD. 
Design: The trial was a double-blinded, randomized, 3-way–crossover, controlled intervention study. Forty-two participants were randomly assigned to consume 2 × 28 g whey protein/d, 2 × 28 g Ca caseinate/d, or 2 × 27 g maltodextrin (control)/d for 8 wk separated by a 4-wk washout. The effects of these interventions were examined with the use of a linear mixed-model ANOVA. 
Results: Thirty-eight participants completed the study. Significant reductions in 24-h BP [for systolic blood pressure (SBP): −3.9 mm Hg; for diastolic blood pressure (DBP): −2.5 mm Hg; P = 0.050 for both)] were observed after whey-protein consumption compared with control intake. After whey-protein supplementation compared with control intake, peripheral and central systolic pressures [−5.7 mm Hg (P = 0.007) and −5.4 mm Hg (P = 0.012), respectively] and mean pressures [−3.7 mm Hg (P = 0.025) and −4.0 mm Hg (P = 0.019), respectively] were also lowered. Flow-mediated dilation (FMD) increased significantly after both whey-protein and calcium-caseinate intakes compared with control intake [1.31% (P < 0.001) and 0.83% (P = 0.003), respectively]. Although both whey protein and calcium caseinate significantly lowered total cholesterol [−0.26 mmol/L (P = 0.013) and −0.20 mmol/L (P = 0.042), respectively], only whey protein decreased triacylglycerol (−0.23 mmol/L; P = 0.025) compared with the effect of the control. Soluble intercellular adhesion molecule 1 and soluble vascular cell adhesion molecule 1 were reduced after whey protein consumption (P = 0.011) and after calcium-caseinate consumption (P = 0.039), respectively, compared with after control intake. 
Conclusions: The consumption of unhydrolyzed milk proteins (56 g/d) for 8 wk improved vascular reactivity, biomarkers of endothelial function, and lipid risk factors. Whey-protein supplementation also lowered 24-h ambulatory SBP and DBP. These results may have important implications for public health. This trial was registered at clinicaltrials.gov as NCT02090842.