B vitamines en omega-3 vetzuren*
Uit een deels Nederlandse studie, weliswaar met ratten blijkt dat voeding rijk aan de B vitamines, foliumzuur, B6 en B12 de aanmaak van omega-3 vetzuren zoals
DHA in het lichaam duidelijk kan verbeteren. De ratten kregen normale voeding (zonder DHA) en verschillende doseringen B vitamines. Zij met in hun voeding de hoogste hoeveelheden van deze B vitamines
(hoger dan normaal geadviseerd) hadden tot wel 70% hogere bloedwaarden DHA.
Combined dietary folate, vitamin B-12, and vitamin B-6 intake influences plasma docosahexaenoic acid concentration in rats
Nick van Wijk1*, Carol J Watkins2, Robert J J Hageman1, John C W Sijben1, Patrick G H J Kamphuis1,3, Richard J Wurtman2 and Laus M Broersen1
· * Corresponding author: Nick van Wijk nick.vanwijk@nutricia.com
Author Affiliations
1 Nutricia Advanced Medical Nutrition, Danone Research, Centre for Specialised Nutrition, PO Box 7005, 6700 CA, Wageningen, The Netherlands
2 Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA
3 Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht, The Netherlands
Nutrition & Metabolism 2012, 9:49 doi:10.1186/1743-7075-9-49
© 2012 van Wijk et al.; licensee BioMed Central Ltd.
Abstract
Background
Folate, vitamin B-12, and vitamin B-6 are essential nutritional components in one-carbon metabolism and are required for methylation capacity. The availability of these vitamins may therefore modify methylation of phosphatidylethanolamine (PE) to phosphatidylcholine (PC) by PE-N-methyltransferase (PEMT) in the liver. It has been suggested that PC synthesis by PEMT plays an important role in the transport of polyunsaturated fatty acids (PUFAs) like docosahexaenoic acid (DHA) from the liver to plasma and possibly other tissues. We hypothesized that if B-vitamin supplementation enhances PEMT activity, then supplementation could also increase the concentration of plasma levels of PUFAs such as DHA. To test this hypothesis, we determined the effect of varying the combined dietary intake of these three B-vitamins on plasma DHA concentration in rats.
Methods
In a first experiment, plasma DHA and plasma homocysteine concentrations were measured in rats that had consumed a B-vitamin-poor diet for 4 weeks after which they were either continued on the B-vitamin-poor diet or switched to a B-vitamin-enriched diet for another 4 weeks. In a second experiment, plasma DHA and plasma homocysteine concentrations were measured in rats after feeding them one of four diets with varying levels of B-vitamins for 4 weeks. The diets provided 0% (poor), 100% (normal), 400% (enriched), and 1600% (high) of the laboratory rodent requirements for each of the three B-vitamins.
Results
Plasma DHA concentration was higher in rats fed the B-vitamin-enriched diet than in rats that were continued on the B-vitamin-poor diet (P = 0.005; experiment A). Varying dietary B-vitamin intake from deficient to supra-physiologic resulted in a non-linear dose-dependent trend for increasing plasma DHA (P = 0.027; experiment B). Plasma DHA was lowest in rats consuming the B-vitamin-poor diet (P > 0.05 vs. normal, P < 0.05 vs. enriched and high) and highest in rats consuming the B-vitamin-high diet (P < 0.05 vs. poor and normal, P > 0.05 vs. enriched). B-vitamin deficiency significantly increased plasma total homocysteine but increasing intake above normal did not significantly reduce it. Nevertheless, in both experiments plasma DHA was inversely correlated with plasma total homocysteine.
Conclusion
These data demonstrate that dietary folate, vitamin B-12, and vitamin B-6 intake can influence plasma concentration of
DHA.
De volledige studie.
(September 2012)
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