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Zwarte rijst tegen vette lever*

Uit een studie, weliswaar met speciale muizen blijkt dat zwarte rijst de door overgewicht veroorzaakte vette lever duidelijk kan verbeteren. In de studie kregen de muizen zeven weken lang of gewone voeding of vette voeding of vette voeding met zwarte rijst extracten. De extra zwarte rijst zorgden voor veel minder schade in de lever, betere bloedwaarden vetten en betere bloedsuikerwaarden.
Black rice (Oryza sativa L.) extract attenuates hepatic steatosis in C57BL/6 J mice fed a high-fat diet via fatty acid oxidation
Hwan-Hee Jang1, Mi-Young Park1, Heon-Woong Kim1, Young-Min Lee1, Kyung-A Hwang1, Jae-Hak Park2, Dong-Sik Park1* and Oran Kwon3* 
· * Corresponding authors: Dong-Sik Park dpark@korea.kr - Oran Kwon orank@ewha.ac.kr 
Nutrition & Metabolism 2012, 9:27 doi:10.1186/1743-7075-9-27
Abstract
Background
Two major risk factors for the onset of fatty liver disease are excessive alcohol intake and obesity, the latter being associated with non-alcoholic fatty liver disease (NAFLD). The aim of this study was to examine the effects of black rice extract (BRE) on hepatic steatosis and insulin resistance in high-fat diet-fed mice, providing a model of NAFLD. 
Methods
Twenty-four mice were randomly divided into three groups (n = 8 in each group): normal fat diet (ND), high fat diet (HF), and high fat diet supplemented with 1% (w/w) BRE (HF +1% BRE). The experimental diets were fed for seven weeks. 
Results
A HF induced hepatic steatosis with significant increases in the serum levels of free fatty acids (FFAs), triglyceride (TG), total cholesterol (TC), and insulin. By contrast, supplementary BRE (10 g/kg of diet) included in the HF alleviated hepatic steatosis and significantly decreased serum TG and TC levels (p < 0.01 for both). Dietary BRE also increased expression of fatty acid metabolism-related genes, including carnitine palmitoyltransferase (CPT1A), acyl-CoA oxidase (ACO), cytochrome P450 (CYP4A10), and peroxisome proliferator activated receptor (PPAR)-α (p < 0.05 for all). 
Conclusions
Dietary BRE supplementation improved serum lipid profiles and significantly enhanced mRNA expression levels of fatty acid metabolism-related genes, primarily via β-oxidation and ω-oxidation in the liver. Taken together, these findings suggest that a BRE-supplemented diet could be useful in reducing the risks of hepatic steatosis and related disorders, including hyperlipidemia and hyperglycemia. 
De volledige studie. (Juni 2012)