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Voeding rijk aan purine verhoogt de kans op jicht aanzienlijk*
Uit een Amerikaanse studie onder 663 vijftigers met jicht blijkt dat zij met de meeste purine in hun voeding tot wel 5x meer kans op een aanval hebben dan zij met de minste purine in hun voeding. Het is vooral de purine in dierlijke voeding die een jichtaanval veroorzaakt, in de plantaardige voeding met purine zitten ook veel bioactieve stoffen die de aanval tegengaan. Voorbeelden van purinerijke voeding zijn orgaanvlees, vis, schaaldieren, gevogelte, linzen en alcohol.
Purine-rich foods intake and recurrent gout attacks
1. Yuqing Zhang1, 2. Clara Chen2, 3. Hyon Choi1,3, 4. Christine Chaisson2, 5. David Hunter4, 6. Jingbo Niu1, 7. Tuhina Neogi1,3
+ Author Affiliations
1. 1Clinical Epidemiology Research and Training Unit, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA 
2. 2Data Coordinating Center, Boston University School of Public Health, Boston, Massachusetts, USA 
3. 3Section of Rheumatology, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA 
4. 4Department of Rheumatology, University of Sydney, New South Wales, Australia 
1. Correspondence to Yuqing Zhang, Boston University, Boston University School of Medicine, 715 Albany Street, A203, Boston, Massachusetts MA 02118, USA; yuqing@bu.edu
Abstract
Objective To examine and quantify the relation between purine intake and the risk of recurrent gout attacks among gout patients. 
Methods The authors conducted a case-crossover study to examine associations of a set of putative risk factors with recurrent gout attacks. Individuals with gout were prospectively recruited and followed online for 1 year. Participants were asked about the following information when experiencing a gout attack: the onset date of the gout attack, clinical symptoms and signs, medications (including antigout medications), and presence of potential risk factors (including daily intake of various purine-containing food items) during the 2-day period prior to the gout attack. The same exposure information was also assessed over 2-day control periods. 
Results This study included 633 participants with gout. Compared with the lowest quintile of total purine intake over a 2-day period, OR of recurrent gout attacks were 1.17, 1.38, 2.21 and 4.76, respectively, with each increasing quintile (p for trend <0.001). The corresponding OR were 1.42, 1.34, 1.77 and 2.41 for increasing quintiles of purine intake from animal sources (p for trend <0.001), and 1.12, 0.99, 1.32 and 1.39 from plant sources (p=0.04), respectively. The effect of purine intake persisted across subgroups by sex, use of alcohol, diuretics, allopurinol, NSAIDs and colchicine. 
Conclusions The study findings suggest that acute purine intake increases the risk of recurrent gout attacks by almost fivefold among gout patients. Avoiding or reducing amount of purine-rich foods intake, especially of animal origin, may help reduce the risk of gout attacks. (Juni 2012)