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Waarom meer allergieën en astma?*
Uit een Duits-Amerikaanse studie, weliswaar met muizen wordt nog eens bevestigd dat een te schone omgeving voor baby’s en peuters de kans op allergieën zoals astma, hooikoorts en autoimmuunziektes duidelijk kan verhogen. De onderzoekers bestudeerden het immuunsystemen van twee groepen pas geboren muizen. De ene groep zonder contact met ziektekiemen en de andere groep in een natuurlijke omgeving met allerlei microben. Muizen in de eerste groep bleken al snel ontstekingen te krijgen in de longen en dikke darm, ontstekingen die op astma en colitis leken. In de tweede groep bleken de muizen al meteen een goed immuunsysteem te ontwikkelen waardoor deze ziektes voorkomen werden. Door deze muizen al vanaf de geboorte in een natuurlijke omgeving met allerlei microben te laten opgroeien blijken ze langdurig beschermd te worden tegen diverse allergieën.
Getting the Dirt On Immunity: Scientists Show Evidence for Hygiene Hypothesis
Previous human studies have suggested that early life exposure to microbes (i.e., germs) is an important determinant of adulthood sensitivity to allergic and autoimmune diseases such as hay fever, asthma and inflammatory bowel disease.
This concept of exposing people to germs at an early age (i.e., childhood) to build immunity is known as the hygiene hypothesis.
Medical professionals have suggested that the hygiene hypothesis explains the global increase of allergic and autoimmune diseases in urban settings. It has also been suggested that the hypothesis explains the changes that have occurred in society and environmental exposures, such as giving antibiotics early in life.
However, neither biologic support nor a mechanistic basis for the hypothesis has been directly demonstrated. Until now.
Researchers at Brigham and Women's Hospital (BWH) have conducted a study that provides evidence supporting the hygiene hypothesis, as well as a potential mechanism by which it might occur.
The study was published online in the journal Science on the Science Express Web site.
The researchers studied the immune system of mice lacking bacteria or any other microbes ("germ-free mice") and compared them to mice living in a normal environment with microbes.
They found that germ-free mice had exaggerated inflammation of the lungs and colon resembling asthma and colitis, respectively. This was caused by the hyperactivity of a unique class of T cells (immune cells) that had been previously linked to these disorders in both mice and humans.
Most importantly, the researchers discovered that exposing the germ-free mice to microbes during their first weeks of life, but not when exposed later in adult life, led to a normalized immune system and prevention of diseases.
Moreover, the protection provided by early-life exposure to microbes was long-lasting, as predicted by the hygiene hypothesis.
"These studies show the critical importance of proper immune conditioning by microbes during the earliest periods of life," said Richard Blumberg, MD, chief for the BWH Division of Gastroenterology, Hepatology and Endoscopy, and co-senior study author, in collaboration with Dennis Kasper, MD, director of BWH's Channing Laboratory and co-senior study author. "Also now knowing a potential mechanism will allow scientists to potentially identify the microbial factors important in determining protection from allergic and autoimmune diseases later in life."
In light of the findings, the researchers caution that further research is still needed in humans.
This research was supported by the National Institutes of Health, Crohns Colitis Foundation of America, Harvard Digestive Diseases Center, Medizinausschuss Schleswig-Holstein, and Deutsche Forschungsgemeinschaft. (April 2012)