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Vitamine D en astma*
Uit een Australische studie onder ruim 2.300 Australische kinderen blijkt dat goede bloedwaarden vitamine D belangrijk zijn bij kinderen ter voorkoming van astma. Lage bloedwaarden vitamine D op zesjarige leeftijd geeft, vooral bij jongens een duidelijk hogere kans op een atopie en daardoor bronchospasmen en astma op veertienjarige leeftijd. Op beide leeftijden bleken lage bloedwaarden vitamine D astma en bronchospasmen duidelijk te verergeren.
Vitamin D and atopy and asthma phenotypes in children: a longitudinal cohort study
1. E.M. Hollams*,#§, 2. P.H. Hart*,#§, 3. B.J. Holt*,#, 4. M. Serralha*,#, 5. F. Parsons*,#, 6. N.H. de Klerk*,#, 7. G. Zhang, 8. P.D. Sly+ and 9. P.G. Holt*⇓
+ Author Affiliations
1. *Telethon Institute for Child Health Research 
2. #Centre for Child Health Research 
3. School of Paediatrics and Child Health, Faculty of Medicine, Dentistry and Health Services, University of Western Australia, Perth, WA
4. +Queensland Children’s Medical Research Institute, University of Queensland, Royal Children’s Hospital, Brisbane, QLD, Australia 
5. §These authors contributed equally 
1. P.G. Holt, Telethon Institute for Child Health, 100 Roberts Road, Subiaco WA 6008, Australia. E-mail: patrick@ichr.uwa.edu.au
Abstract
Vitamin D has been linked in some studies with atopy- and asthma-associated phenotypes in children with established disease, but its role in disease inception at the community level is less clear. The aim of the present study was to investigate associations between vitamin D status and biological signatures indicative of allergy and asthma development in children aged 6 and 14 years in Perth, WA, Australia (latitude 32° S). 
Serum vitamin D was assayed in 989 6-yr-olds and 1,380 14-yr-olds from an unselected community birth cohort; 689 subjects were assessed at both ages. Vitamin D levels were assessed as a risk modifier for respiratory and allergic outcomes at both ages, using previously ascertained phenotypic data. The predictive value of vitamin D levels at age 6 yrs for development of clinical phenotypes at age 14 yrs was also examined. 
Serum vitamin D levels in children of both ages were negatively associated with concurrent allergic phenotypes; sex stratification revealed that this association was restricted mainly to males. Furthermore, vitamin D levels at age 6 yrs were significant predictors of subsequent atopy/asthma-associated phenotypes at age 14 yrs. 
In an unselected community setting, children (particularly males) with inadequate vitamin D are at increased risk of developing atopy, and subsequently bronchial hyperresponsiveness (BHR) and asthma. In a large unselected cohort, males with inadequate vitamin D at 6 and 14 yrs of age had increased atopy and BHR. Low vitamin D at age 6 yrs was a predictor of atopy and asthma at 14 yrs of age. (Maart 2012)