Brazilnoten voor lager cholesterol*
Uit een studie onder jong volwassenen met flink overgewicht blijkt dat het regelmatig eten van
brazilnoten het cholesterol duidelijk doet dalen, zorgt voor hogere bloedwaarden
selenium en voor betere functies van de kleine bloedvaten. In de studie kregen de deelnemers zestien weken lang dagelijks 3-5 noten. Ook uit deze studie blijkt dat noten niet voor gewichtstoename zorgen.
Brazil nuts intake improves lipid profile, oxidative stress and microvascular function in obese adolescents: a randomized controlled trial
Priscila A Maranhão1, Luiz G Kraemer-Aguiar2*, Cecilia L de Oliveira3, Maria CC Kuschnir4, Yasmine R Vieira1, Maria GC Souza5, Josely C Koury6 and Eliete Bouskela7
· * Corresponding author: Luiz G Kraemer-Aguiar gkraemer@ig.com.br
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Nutrition & Metabolism 2011, 8:32 doi:10.1186/1743-7075-8-32
Abstract
Background
Obesity is a chronic disease associated to an inflammatory process resulting in oxidative stress that leads to morpho-functional microvascular damage that could be improved by some dietary interventions. In this study, the intake of Brazil nuts (Bertholletia excelsa), composed of bioactive substances like selenium, α- e γ- tocopherol, folate and polyunsaturated fatty acids, have been investigated on antioxidant capacity, lipid and metabolic profiles and nutritive skin microcirculation in obese adolescents.
Methods
Obese female adolescents (n = 17), 15.4 ± 2.0 years and BMI of 35.6 ± 3.3 kg/m2, were randomized 1:1 in two groups with the diet supplemented either with Brazil nuts [BNG, n = 08, 15-25 g/day (equivalent to 3 to 5 units/day)] or placebo [PG (lactose), n = 09, one capsule/day] and followed for 16 weeks. Anthropometry, metabolic-lipid profiles, oxidative stress and morphological (capillary diameters) and functional [functional capillary density, red blood cell velocity (RBCV) at baseline and peak (RBCVmax) and time (TRBCVmax) to reach it during post-occlusive reactive hyperemia, after 1 min arterial occlusion] microvascular variables were assessed by nailfold videocapillaroscopy at baseline (T0) and after intervention (T1).
Results
T0 characteristics were similar between groups. At T1, BNG (intra-group variation) had increased selenium levels (p = 0.02), RBCV (p = 0.03) and RBCVmax (p = 0.03) and reduced total (TC) (p = 0.02) and LDL-cholesterol (p = 0.02). Compared to PG, Brazil nuts intake reduced TC (p = 0.003), triglycerides (p = 0.05) and LDL-ox (p = 0.02) and increased RBCV (p = 0.03).
Conclusion
Brazil nuts intake improved the lipid profile and microvascular function in obese adolescents, possibly due to its high level of unsaturated fatty acids and bioactive substances.
Trial Registration
Clinical Trials.gov NCT00937599
De volledige studie.
(November 2011)
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