Groene thee tegen overgewicht*
Uit een studie weliswaar met muizen blijkt dat het drinken van groene thee
overgewicht kan tegengaan. De muizen die behalve een vetrijk dieet ook groene
thee-extracten (met epigallo catechine gallaat (EGCG)) kregen bleken bijna de helft minder snel aan te komen en bleken bovendien wel 30%
minder vet op te nemen dan de muizen met alleen het vetrijk dieet. De hoeveelheid in deze studie was redelijk hoog, vergelijkbaar met 10 koppen thee per dag voor mensen, doch
wel in combinatie met een vetrijk dieet. Andere studies laten zien dat een paar
koppen groene thee per dag ook al goed helpen met afvallen.
Green Tea Helps Mice Keep Off Extra Pounds
Green tea may slow down weight gain and serve as another tool in the fight against obesity, according to Penn State food scientists.
Obese mice that were fed a compound found in green tea along with a high-fat diet gained weight significantly more slowly than a control group of mice that did not receive the green tea supplement, said Joshua Lambert, assistant professor of food science in agricultural sciences.
"In this experiment, we see the rate of body weight gain slows down," said Lambert.
The researchers, who released their findings in the current online version of Obesity, fed two groups of mice a high-fat diet. Mice that were fed Epigallocatechin-3-gallate -- EGCG -- a compound found in most green teas, along with a high-fat diet, gained weight 45 percent more slowly than the control group of mice eating the same diet without EGCG.
"Our results suggest that if you supplement with EGCG or green tea you gain weight more slowly," said Lambert.
In addition to lower weight gain, the mice fed the green tea supplement showed a nearly 30 percent increase in fecal lipids, suggesting that the EGCG was limiting fat absorption, according to Lambert.
"There seems to be two prongs to this," said Lambert. "First, EGCG reduces the ability to absorb fat and, second, it enhances the ability to use fat."
The green tea did not appear to suppress appetite. Both groups of mice were fed the same amount of high-fat food and could eat at any time.
"There's no difference in the amount of food the mice are eating," said Lambert. "The mice are essentially eating a milkshake, except one group is eating a milkshake with green tea."
A person would need to drink ten cups of green tea each day to match the amount of EGCG used in the study, according to Lambert. However, he said recent studies indicate that just drinking a few cups of green tea may help control weight.
"Human data -- and there's not a lot at this point -- shows that tea drinkers who only consume one or more cups a day will see effects on body weight compared to nonconsumers," said Lambert.
Lambert, who worked with Kimberly Grove and Sudathip Sae-tan, both graduate students in food science, and Mary Kennett, professor of veterinary and biomedical sciences, said that other experiments have shown that lean mice did not gain as much weight when green tea is added to a high fat diet. However, he said that studying mice that are already overweight is more relevant to humans because people often consider dietary changes only when they notice problems associated with obesity.
"Most people hit middle age and notice a paunch; then you decide to eat less, exercise and add green tea supplement," said Lambert.
The National Institutes of Health supported this work.
(−)-Epigallocatechin-3-gallate Inhibits Pancreatic Lipase and Reduces Body Weight Gain in High Fat-Fed Obese Mice
Kimberly A. Grove, Sudathip Sae-tan, Mary J. Kennett and Joshua D. Lambert
Abstract
Tea (Camellia sinensis, Theaceae) has been shown to have obesity preventive effects in laboratory studies. We hypothesized that dietary epigallocatechin-3-gallate (EGCG) could reverse metabolic syndrome in high fat-fed obese C57bl/6J mice, and that these effects were related to inhibition of pancreatic lipase (PL). Following treatment with 0.32% EGCG for 6 weeks, a 44% decrease in body weight (BW) gain in high fat-fed, obese mice (P < 0.01) was observed compared to controls. EGCG treatment increased fecal lipid content by 29.4% (P < 0.05) compared to high fat-fed control, whereas in vitro, EGCG dose-dependently inhibited PL (IC50 = 7.5 µmol/l) in a noncompetitive manner with respect to substrate concentration. (−)-Epicatechin-3-gallate exhibited similar inhibitory activity, whereas the nonester-containing (−)-epigallocatechin did not. In conclusion, EGCG supplementation reduced final BW and BW gain in obese mice, and some of these effects may be due to inhibition of PL by
EGCG. (Oktober 2011)
Reacties:
