Vitamine D verkleint de kans op diabetes*
Uit een Amerikaanse studie onder ruim twee duizend personen met een verhoogde kans op
diabetes lijkt dat goede bloedwaarden vitamine D de kans op het krijgen van diabetes type-2 flink kan verminderen. Deelnemers met goede bloedwaarden van gemiddeld 30 ng/ml hadden 26% minder kans op het krijgen van diabetes dan zij met slechte bloedwaarden van gemiddeld 13 ng/ml. Zij met
bloedwaarden van 50 ng/ml of meer hadden zelfs 56% minder kans op het krijgen diabetes dan zij met slechte bloedwaarden vitamine D. Uit eerdere studies is
al gebleken dat bij lage bloedwaarden vitamine D het voor het lichaam moeilijk
wordt om voldoende insuline aan te maken.
Vitamin D Status and Progression to Diabetes in Patients at Risk for Diabetes: An Ancillary Analysis in the Diabetes Prevention Program Randomized Controlled Trial
Abstract No: 0117-OR
Abstract Type: Oral
Author(s): ANASTASSIOS G. PITTAS, JASON NELSON, JOANNA MITRI, WILLIAM HILLMANN, CHERYL GARGANTA, DAVID NATHAN, FRANK HU, BESS DAWSON-HUGHES, DIABETES PREVENTION PROGRAM RESEARCH GROUP
Location(s): Boston, MA
Abstract Body:
The objective of the study was to investigate the association between vitamin D status and risk of incident diabetes in the Diabetes Prevention Program (DPP), a 3-arm trial comparing intensive lifestyle modification or metformin vs. placebo for prevention of diabetes in patients with pre-diabetes.
Over a mean 3.2-year follow-up period, we assessed the association between plasma 25OHD, measured at yearly intervals, and incident diabetes in the cohort of 2,039 participants randomized to either intensive lifestyle (n=1,017) or placebo (n=1,022). Analyses were adjusted for age, gender, BMI, race, UV index, family history of diabetes, hypertension, smoking, alcohol consumption, C-reactive protein, kidney function, physical activity and intervention. Variables measured at multiple study time points (25OHD, BMI and physical activity) entered the analyses as time-varying “lagged” covariates.
After multivariate adjustment, participants in the highest tertile of 25OHD (median 25OHD 30.1 ng/mL) had a hazard ratio of 0.74 (95%CI, 0.59 to 0.93) for developing diabetes compared to participants in the lowest tertile (median 25OHD 12.8 ng/mL). When analyses were repeated by categories of 25OHD based on cut-points suggested by the 2010 Institute of Medicine Dietary Reference Intake report on calcium and vitamin D, there appeared to be a 'dose-effect' with the hazard ratio for incident diabetes being lowest (0.46; 95%CI, 0.23 to 0.90) in the highest category (25OHD ≥50 ng/mL) compared to the lowest category (25OHD <12 ng/mL) with no evidence of a threshold. In subgroup analyses by tertiles, the association was in the same direction in placebo (0.72; 95%CI 0.53, 0.96) vs. lifestyle arm (0.80; 95%CI 0.54, 1.14) (p=0.67 for interaction).
Higher vitamin D status, assessed repeatedly during the follow-up period, is associated with lower risk of diabetes among persons at high risk for diabetes, even after adjusting for lifestyle interventions known to decrease diabetes risk. The role of vitamin D in reducing diabetes risk needs to be confirmed in vitamin D supplementation trials. (Augustus 2011)
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