Kurkuma tegen nierschade bij diabetes*
Uit een studie, weliswaar met ratten blijkt dat het kruid kurkuma zeer goede resultaten geeft tegen diabetische nefropathie, een situatie waarbij de
nieren niet goed meer werken. In de studie kregen een deel van de ratten met
diabetes iedere dag extra kurkuma (100 mg/kg lichaamsgewicht) en dat voor 8 weken. Kurkuma beschermde de ratten tegen diabetische nefropathie doordat de toename van NF-kappaB, een transcriptiefactor, eiwitcomplex dat (onder andere) bij immuun- en ontstekingsprocessen een belangrijke rol speelt, erdoor flink geremd wordt.
Curcumin ameliorates macrophage infiltration by inhibiting NF-kappaB activation and proinflammatory cytokines in streptozotocin induced-diabetic nephropathy
Vivian Soetikno, Flori R Sari, Punniyakoti T Veeraveedu, Rajarajan A Thandavarayan, Meilei Harima, Vijayakumar Sukumaran, Arun PRASATH Lakshmanan, Kenji Suzuki, Hiroshi Kawachi and Kenichi Watanabe
Nutrition & Metabolism 2011, 8:35 doi:10.1186/1743-7075-8-35
Abstract (provisional)
Background
Chronic inflammation plays an important role in the progression of diabetic nephropathy (DN) and that the infiltration of macrophages in glomerulus has been implicated in the development of glomerular injury. We hypothesized that the plant polyphenolic compound curcumin, which is known to exert potent anti-inflammatory effect, would ameliorate macrophage infiltration in streptozotocin (STZ)-induced diabetic rats.
Methods
Diabetes was induced with STZ (55 mg/kg) by intraperitoneal injection in rats. Three weeks after STZ injection, rats were divided into three groups, namely, control, diabetic, and diabetic treated with curcumin at 100 mg/kg/day, p.o., for 8 weeks. The rats were sacrificed 11 weeks after induction of diabetes. The excised kidney was used to assess macrophage infiltration and expression of various inflammatory markers.
Results
At 11 weeks after STZ injection, diabetic rats exhibited renal dysfunction, as evidenced by reduced creatinine clearance, increased blood glucose, blood urea nitrogen and proteinuria, along with marked reduction in the body weight. All of these abnormalities were significantly reversed by curcumin. Hyperglycemia induced the degradation of IkappaBalpha and NF-kappaB activation and as a result increased infiltration of macrophages (52%) as well as increased proinflammatory cytokines: TNF-alpha and IL-1beta. Curcumin treatment significantly reduced macrophage infiltration in the kidneys of diabetic rats, suppressed the expression of above proinflammatory cytokines and degradation of IkappaBalpha. In addition, curcumin treatment also markedly decreased ICAM-1, MCP-1 and TGF-beta1 protein expression. Moreover, at nuclear level curcumin inhibited the NF-kappaB activity.
Conclusion
Our results suggested that curcumin treatment protect against the development of DN in rats by reducing macrophage infiltration through the inhibition of NF-kappaB activation in STZ-induced diabetic rats.
Het
artikel. (Juni 2011)
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