Vitamine D verbetert ademhaling
COPD-patiënten*
Uit een kleine Belgische studie onder vijftig patiënten blijkt dat goede
bloedwaarden vitamine D de ademhaling en het uithoudingsvermogen bij patiënten met
COPD duidelijk kunnen verbeteren. De studie
duurde 3 maanden en in die 3 maanden kreeg de helft van de deelnemers maandelijks 2.500 mcg vitamine D3, de andere helft een placebo. In de vitamine D-groep stegen de
bloedwaarden vitamine D van 22 ng/ml tot 53
ng/ml na 3 maanden. De patiënten in de vitamine D-groep bleken na verloop minder moeite te hebben met ademhalen en met bewegen dan de
patiënten in de placebogroep. De VO2max of het maximale zuurstofopnamevermogen was in de vitamine D-groep duidelijk hoger en ook in een zes minuten looptest scoorden deze patiënten beter. Volgens de onderzoekster Hornikx is verder onderzoek noodzakelijk, vooral om te onderzoeken hoe vitamine D de functie van de spieren verbetert. De resultaten van de studie zijn gepresenteerd op de 2011 American Thoracic Society International Conference in Denver.
Vitamin D May Aid COPD Pulmonary Rehab
High doses of vitamin D appear to help chronic obstructive pulmonary disease (COPD) patients do better in pulmonary rehabilitation programs, a researcher said
here.
In a small three-month randomized trial, patients getting vitamin D saw significant improvements in their maximal oxygen
consumption, according to Miek Hornikx, a doctoral student at the Catholic University of Leuven in Leuven,
Belgium.
They also saw a trend toward improvements in maximal workload and six-minute walk
distance, Hornikx reported here at the annual meeting of the American Thoracic Society.
On the other hand, possibly because the study was short, there were no differences in quality of
life, Hornikx told reporters at a press conference at which the research was
discussed.
It's well known, Hornikx said, that people with COPD commonly have a deficiency in vitamin D: they don't get out much and their physical activity is
limited.
Low levels of the vitamin have been linked with muscle weakness, so she and colleagues wanted to see if supplements might benefit COPD patients undergoing
rehabilitation.
To test the issue, the researchers enrolled 50 patients with a history of exacerbations who had been referred for rehab and assigned them randomly to get 100,000 IU of vitamin a month for three months or a placebo. The
dose, Hornikx told reporters, is about four times the recommended dose over a
month.
The outcomes were changes in a range of markers – peripheral and respiratory muscle
force, the six-minute walk, oxygen consumption (VO2max), maximal workload (Wmax), and quality of
life, Hornikx reported.
Patients in the vitamin D arm were slightly younger (67 on average compared with 69) and had slightly better lung function as measured by one-second forced expiratory volume (46% of predicted FEV1 compared with 40% of
predicted).
The treatment resulted, not surprisingly, in a significant improvement in vitamin D in patients in the treated arm, from 22 monograms per milliliter of 25-hydroxyvitamin D at baseline to 53 after three
months. The change was significant at P=0.0001.
The researchers found that vitamin D patients:
· Had a 0.11 liter per minute improvement in VO2max, compared with a loss of 0.02 liters per minute in the placebo arm, a difference that was significant at P=0.029.
· Gained 36 meters on average in the six-minute walk test, compared with 11 in the placebo
patients, although the difference did not reach significance, at P=0.179.
· Had trends toward improvement in Wmax and both peripheral and respiratory muscle
force.
Improvements in FEV1 were similar between the groups.
Primary source: American Journal of Respiratory and Critical Care Medicine
Source reference:
Hornikx M, et al "Vitamin D supplementation during rehabilitation in patients with chronic obstructive pulmonary
disease: An intervention study" Am J Respir Crit Care Med 2011; 183: A2533.
(Mei 2011)
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