Koffie tegen borstkanker*
Uit een Zweeds onderzoek blijkt dat koffie drinken de kans op
borstkanker duidelijk kan verminderen. Het onderzoek ging onder bijna zesduizend Zweedse vrouwen van 50 jaar en ouder. Zij die 5 koppen koffie per dag dronken hadden tot 20% minder kans op het krijgen van borstkanker en wel bijna 60% minder kans op het krijgen van het type borstkanker oestrogeenreceptor-negatief, een moeilijk te behandelen vorm van borstkanker in vergelijking met zij
die weinig of hooguit 1 kop koffie per dag dronken.
De
onderzoekers wijzen er op dat uit eerdere onderzoeken blijkt dat er ook risico's
aan het drinken van veel koffie kunnen zitten.
Coffee consumption modifies risk of estrogen-receptor negative breast cancer
Jingmei Li , Petra Seibold , Jenny Chang-Claude , Dieter Flesch-Janys , Jianjun Liu , Kamila Czene , Keith Humphreys and Per Hall
Breast Cancer Research 2011, 13:R49doi:10.1186/bcr2879
Abstract (provisional)
Introduction
Breast cancer is a complex disease and may be sub-divided into hormone-responsive (estrogen receptor (ER) positive) and non-hormone-responsive subtypes (ER-negative). Some evidence suggests that heterogeneity exists in the associations between coffee consumption and breast cancer risk, according to different estrogen receptor subtypes. We assessed the association between coffee consumption and postmenopausal breast cancer risk in a large population-based study (2,818 cases and 3,111 controls), overall, and stratified by ER tumour subtypes.
Methods
Odds ratios (OR) and corresponding 95% confidence intervals (CI) were estimated using the multivariate logistic regression models fitted to examine breast cancer risk in a stratified case-control analysis. Heterogeneity among ER subtypes was evaluated in a case-only analysis, by fitting binary logistic regression models, treating ER status as a dependent variable, with coffee consumption included as a covariate.
Results
In the Swedish study, coffee consumption was associated with a modest decrease in overall breast cancer risk in the age-adjusted model (OR>5 cups/day compared to OR[less than or equal to]1 cup/day: 0.80, 95% CI: 0.64, 0.99, P trend = 0.028). In the stratified case-control analyses, a significant reduction in the risk of ER-negative breast cancer was observed in heavy coffee drinkers (OR>5 cups/day compared to OR[less than or equal to]1 cup/day : 0.43, 95% CI: 0.25, 0.72, P trend = 0.0003) in a multivariate-adjusted model. The breast cancer risk reduction associated with higher coffee consumption was significantly higher for ER-negative compared to ER-positive tumours (P heterogeneity (age-adjusted) = 0.004).
Conclusions
A high daily intake of coffee was found to be associated with a statistically significant decrease in ER-negative breast cancer among postmenopausal
women. (Mei 2011)
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