Granaatappelsap
kan uitzaaiing prostaatkanker remmen*
Volgens een Amerikaanse studie, weliswaar nog in het laboratorium kunnen
bioactieve stoffen in granaatappelsap er voor zorgen dat
prostaatkanker minder
snel uitzaait. Uitgezaaide prostaatkanker kan tot nu toe niet helemaal worden genezen. Wanneer deze kanker terugkomt, wordt een behandeling ingezet waarbij het mannelijke hormoon testosteron wordt onderdrukt, zodat de kanker niet verder kan uitzaaien. Maar uiteindelijk wordt de kanker resistent voor testosteron en zaait de ziekte uit naar bot, longen en
lymfen. In het laboratorium zagen de onderzoekers dat kankercellen die behandeld waren
met granaatappelsap zich niet zo makkelijk deelden en ook minder makkelijk losbraken.
Verder onderzoek, in vivo zal nodig zijn.
Pomegranate Juice Components Could Stop Cancer from Spreading, Research Suggests
Researchers at the University of California, Riverside have identified components in pomegranate juice that both inhibit the movement of cancer cells and weaken their attraction to a chemical signal that promotes the metastasis of prostate cancer to the bone. The research could lead to new therapies for preventing cancer metastasis.
Performed in the lab of Manuela Martins-Green, a professor of cell biology, the research was presented Dec. 12, 2010 at the 50th annual meeting of the American Society for Cell Biology taking place in Philadelphia.
Prostate cancer is the second-leading cause of cancer-related deaths in men in the United States. To date, there is no cure for it. If prostate cancer recurs after treatments of surgery and/or radiation, usually the next treatment is the suppression of the male hormone testosterone, which inhibits the growth of the cancer cells because they need this hormone to grow. But over time, the cancer develops ways to resist hormone suppression therapies, becomes very aggressive, and metastasizes to the bone marrow, lungs, and lymph nodes, usually resulting in the patient's death.
The Martins-Green lab applied pomegranate juice on laboratory-cultured prostate cancer cells that were resistant to testosterone (the more resistant a cancer cell is to testosterone, the more prone it is to metastasizing).
The researchers -- Martins-Green, graduate student Lei Wang and undergraduate students Andre Alcon and Jeffrey Ho -- found that the pomegranate juice-treated tumor cells that had not died with the treatment showed increased cell adhesion (meaning fewer cells breaking away) and decreased cell migration.
Next, the researchers identified the following active groups of ingredients in pomegranate juice that had a molecular impact on cell adhesion and migration in metastatic prostate cancer cells: phenylpropanoids, hydrobenzoic acids, flavones and conjugated fatty acids.
"Having identified them, we can now modify cancer-inhibiting components in pomegranate juice to improve their functions and make them more effective in preventing prostate cancer metastasis, leading to more effective drug therapies," Martins-Green said. "Because the genes and proteins involved in the movement of prostate cancer cells are essentially the same as those involved in the movement of other types of cancer cells, the same modified components of the juice could have a much broader impact in cancer treatment."
Martins-Green explained that an important protein produced in the bone marrow causes the cancer cells to move to the bone where they can then form new tumors.
"We show that pomegranate juice markedly inhibits the function of this protein, and thus this juice has the potential of preventing metastasis of the prostate cancer cells to the bone," Martins-Green said.
Next, her lab plans to do additional tests in an in vivo model for prostate cancer metastasis to determine whether the same cancer-inhibiting components that work in cultured cells can prevent metastasis without side
effects. (December 2010)
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