Stress op middelbare leeftijd verdubbelt de kans op de ziekte van Alzheimer*
Uit een vijfendertig jaar lopende Zweedse studie onder ruim 1.400 vrouwen blijkt dat
stress op middelbare leeftijd de kans op het krijgen van de
ziekte van Alzheimer duidelijk doet verhogen. Voor het eerst werden de vrouwen in 1968 onderzocht en wederom in 1974, 1980, 1992 en 2000. Zij die wel eens stressperiodes hadden bleken 65% meer kans te hebben. Zij die op drie peilmomenten een stressperioden hadden bleken wel 100% meer kans te hebben op het krijgen van de ziekte van Alzheimer.
Stress during middle age can increase a woman's risk of developing Alzheimer's disease, a new study suggests. Swedish researchers found that those who reported high levels of stress and anxiety during middle age were up to twice as likely to develop dementia as women who did not report consistent periods of stress.
Stress in middle age could contribute to late-life dementia
Psychological stress in middle age could lead to the development of dementia later in life, especially Alzheimer's disease, reveals research from the University of Gothenburg, Sweden. Based on data from a study which followed women for 35 years, this is the first research in Sweden to indicate a link between stress and dementia.
The research, published in prestigious scientific journal Brain, is based on a major population study of women from Gothenburg. A representative sample of women were examined for the first time in 1968 when aged between 38 and 60, and then re-examined in 1974, 1980, 1992 and 2000.
A question about psychological stress was included in the 1968, 1974 and 1980 surveys and was answered by 1,415
women.
"Stress was defined as a sense of irritation, tension, nervousness, anxiety, fear or sleeping problems lasting a month or more due to work, health, family or other problems," explains Lena Johansson, a researcher from the Neuropsychiatric Epidemiology Unit at the Sahlgrenska Academy's Department of Psychiatry and Neurochemistry at the University of Gothenburg.
During the 35 years of the study, 161 of the participants developed dementia, mainly in the form of Alzheimer's disease. The risk of dementia was about 65% higher in women who reported repeated periods of stress in middle age than in those who did not. In women who reported stress in all three surveys, the risk more than doubled.
"This is the first study to show that stress in middle age can lead to dementia in old age, and confirms similar findings from studies of animals. Stress has previously been shown to increase the risk of cardiovascular diseases such as stroke, heart attack and hypertension," says Johansson, who also refers to earlier research at the Sahlgrenska Academy showing that cardiovascular disease can lead to Alzheimer's.
"This study could result in a better understanding of the risk factors for dementia, but our results need to be confirmed by other studies, and further research is needed in the area. Most of those who said that they were stressed did not develop dementia, so it's not currently possible to advise people to be less stressed or warn about the dangers of high stress levels due to an increased risk of developing dementia."
Provided by University of Gothenburg (December 2010)
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