Home / Nieuws / ...

Antioxidanten goed tegen hart- en vaatziektes*
Uit een Israëlische studie blijkt dat supplementen van antioxidanten goed zijn tegen hart- en vaatziektes. In de studie kregen de deelnemers, allemaal met meerdere risicofactoren voor hart- en vaatziektes, twee maal daags of een placebo of een supplement met 500 mg vitamine C, 133 mg vitamine E, 60 mg Q10 en 100 mcg selenium. Na zes maanden bleek de supplementengroep duidelijk soepelere bloedvaten een hoger HDL (goede cholesterol) en minder ontstekingsmarkers te hebben.
Effect of long-term treatment with antioxidants (vitamin C, vitamin E, coenzyme Q10 and selenium) on arterial compliance, humoral factors and inflammatory markers in patients with multiple cardiovascular risk factors
Marina Shargorodsky1,2,3 , Ortal Debby2 , Zipora Matas2,5 and Reuven Zimlichman2,3,4,5 
1 Department of Endocrinology, Wolfson Medical Center, Holon, 58100, Israel
2 Brunner Institute for Cardiovascular Research, Wolfson Medical Center, Holon, 58100, Israel
3 Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
4 Department of Biochemistry, Wolfson Medical Center, Holon, 58100, Israel
5 Department of Medicine, Wolfson Medical Center, Holon, 58100, Israel
author email corresponding author email
Nutrition & Metabolism 2010, 7:55doi:10.1186/1743-7075-7-55
Abstract
Background
Antioxidant supplementations have the potential to alleviate the atherosclerotic damage caused by excessive production of reactive oxygen species (ROS). The present study evaluated the effects of prolonged antioxidant treatment on arterial elasticity, inflammatory and metabolic measures in patients with multiple cardiovascular risk factors.
Methods
Study participants were randomly assigned to two groups. Group 1 received oral supplementation with 2 capsules per day of Mid Life Guard, SupHerb, Israel. In each capsule vitamin C (500 mg) vitamin E (200 iu), co-enzyme Q10 (60 mg) and selenium (100 mcg), Group 2 received matching placebo(SupHerb) for 6 months. Patients were evaluated for lipid profile, HbA1C, insulin, C-peptide, hs-CRP, endothelin, aldosterone, plasma renin activity and Homeostasis model assessment-insulin resistance (HOMA-IR). Arterial elasticity was evaluated using pulse wave contour analysis (HDI CR 2000, Eagan, Minnesota).
Results
Antioxidant-treated patients exhibited significant increases in large arterial elasticity index (LAEI) as well as small arterial elasticity index (SAEI). A significant decline HbA1C and a significant increase in HDL-cholesterol were also observed. In the placebo group, significant changes in LAEI, SAEI or metabolic measures were not observed.
Conclusions
Antioxidant supplementation significantly increased large and small artery elasticity in patients with multiple cardiovascular risk factors. This beneficial vascular effect was associated with an improvement in glucose and lipid metabolism as well as decrease in blood pressure. (Oktober 2010)