Eiwitrijkdieet en de kans op diabetes*
De meeste voedingsadviezen ter voorkoming van diabetes zijn hoofdzakelijk gericht op minder vet en koolhydraten. Uit een Europese studie nu blijkt dat een dieet rijk aan dierlijke
eiwitten de kans op diabetes flink doet toenemen. Een totale inname aan eiwitten had vergelijkbare resultaten. Plantaardige eiwitten alleen had geen relatie tot diabetes, De studie werd uitgevoerd door Nederlandse wetenschappers onder ruim 38.000 deelnemers die 10 jaar lang gevolgd werden.
Dietary Intake of Total, Animal, and Vegetable Protein and Risk of Type 2 Diabetes in the European Prospective Investigation into Cancer and Nutrition (EPIC)-NL Study
1. Ivonne Sluijs, MSC1,
2. Joline W.J. Beulens, PHD1,2,
3. Daphne L. van der A, PHD3,
4. Annemieke M.W. Spijkerman, PHD2,
5. Diederick E. Grobbee, MD, PHD1 and
6. Yvonne T. van der Schouw, PHD1
+ Author Affiliations
1. 1Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands;
2. 2Center for Prevention and Health Services Research, National Institute for Public Health and the Environment, Bilthoven, the Netherlands;
3. 3Center for Nutrition and Health, National Institute for Public Health and the Environment, Bilthoven, the Netherlands.
1. Corresponding author: Ivonne Sluijs, i.sluijs-2@umcutrecht.nl.
Abstract
OBJECTIVE Dietary recommendations are focused mainly on relative dietary fat and carbohydrate content in relation to diabetes risk. Meanwhile, high-protein diets may contribute to disturbance of glucose metabolism, but evidence from prospective studies is scarce. We examined the association among dietary total, vegetable, and animal protein intake and diabetes incidence and whether consuming 5 energy % from protein at the expense of 5 energy % from either carbohydrates or fat was associated with diabetes risk.
RESEARCH DESIGN AND METHODS A prospective cohort study was conducted among 38,094 participants of the European Prospective Investigation into Cancer and Nutrition (EPIC)-NL study. Dietary protein intake was measured with a validated food frequency questionnaire. Incident diabetes was verified against medical records.
RESULTS During 10 years of follow-up, 918 incident cases of diabetes were documented. Diabetes risk increased with higher total protein (hazard ratio 2.15 [95% CI 1.77–2.60] highest vs. lowest quartile) and animal protein (2.18 [1.80–2.63]) intake. Adjustment for confounders did not materially change these results. Further adjustment for adiposity measures attenuated the associations. Vegetable protein was not related to diabetes. Consuming 5 energy % from total or animal protein at the expense of 5 energy % from carbohydrates or fat increased diabetes risk.
CONCLUSIONS Diets high in animal protein are associated with an increased diabetes risk. Our findings also suggest a similar association for total protein itself instead of only animal sources. Consumption of energy from protein at the expense of energy from either carbohydrates or fat may similarly increase diabetes risk. This finding indicates that accounting for protein content in dietary recommendations for diabetes prevention may be
useful.
Diabetes Care (Februari 2010)
