Goede voeding ter voorkoming van hartproblemen bij diabetici*
Voeding rijk aan cafeïnezuur en ellagitannines blijkt bij diabetici de kans op hartproblemen tegen te gaan. Althans dat blijkt uit deze Chinese studie, weliswaar met muizen. De diabetische muizen kregen of een normaal dieet of een dieet waarvan 2% cafeïnezuur of een dieet met 2% ellagitannines. Na drie maanden werden de muizen onderzocht en zij met het cafeïnezuur- en het ellagitanninesdieet bleken flink minder risicofactoren te hebben voor het ontstaan van hartproblemen zoals cardiomyopathie,
een ziekte van de hartspier.
Anti-inflammatory and anti-coagulatory activities of caffeic acid and ellagic acid in cardiac tissue of diabetic mice
Pei-chun Chao1,2 , Cheng-chin Hsu1 and Mei-chin Yin3
1Department of Nutritional Science, Chung Shan Medical University, Taichung City, Taiwan, Republic of China
2Department of Nutrition, Chung Shan Medical University Hospital, Taichung City, Taiwan, Republic of China
3Department of Nutrition, China Medical University, Taichung City, Taiwan, Republic of China
author email corresponding author email
Nutrition & Metabolism 2009, 6:33doi:10.1186/1743-7075-6-33
The electronic version of this article is the complete one and can be found online at:
http://www.nutritionandmetabolism.com/content/6/1/33
© 2009 Chao et al; licensee BioMed Central Ltd.
Abstract
Background
Caffeic acid (CA) and ellagic acid (EA) are phenolic acids naturally occurring in many plant foods. Cardiac protective effects of these compounds against dyslipidemia, hypercoagulability, oxidative stress and inflammation in diabetic mice were examined.
Methods
Diabetic mice were divided into three groups (15 mice per group): diabetic mice with normal diet, 2% CA treatment, or 2% EA treatment. One group of non-diabetic mice with normal diet was used for comparison. After 12 weeks supplement, mice were sacrificed, and the variation of biomarkers for hypercoagulability, oxidative stress and inflammation in cardiac tissue of diabetic mice were measured.
Results
The intake of CA or EA significantly increased cardiac content of these compounds, alleviated body weight loss, elevated plasma insulin and decreased plasma glucose levels in diabetic mice (p < 0.05). These treatments also significantly enhanced plasma antithrombin-III and protein C activities (p < 0.05); and decreased triglyceride content in cardiac tissue and plasma (p < 0.05), in which the hypolipidemic effects of EA were significantly greater than that of CA (p < 0.05). CA or EA significantly lowered cardiac levels of malondialdehyde, reactive oxygen species, interleukin (IL)-beta, IL-6, tumor necrosis factor (TNF)-alpha and monocyte chemoattractant protein (MCP)-1 (p < 0.05); and retained cardiac activity of glutathione peroxidase (GPX), superoxide dismutase (SOD) and catalase (p < 0.05). These compounds also significantly up-regulated cardiac mRNA expression of GPX1, SOD and catalase; and down-regulated IL-1beta, IL-6, TNF-alpha and MCP-1 mRNA expression in diabetic mice (p < 0.05).
Conclusion
These results support that CA and EA could provide triglyceride-lowering, anti-coagulatory, anti-oxidative, and anti-inflammatory protection in cardiac tissue of diabetic mice. Thus, the supplement of these agents might be helpful for the prevention or attenuation of diabetic
cardiomyopathy.
(Oktober
2009)
