Vitamine D tegen chronische pijn*
Uit een Engelse studie onder een kleine 7.000 mensen van 45 jaar en ouder blijkt dat voldoende
vitamine D de kans op chronische pijn flink kan doen afnemen althans bij vrouwen, bij mannen werd dit voordeel niet vastgesteld. 8% van de vrouwen met bloedwaarde vitamine D tussen 30 en 40 ng/ml hadden
chronische pijn tegen 14% met bloedwaarden lager dan 10 ng/ml. Waarom dit voordeel alleen voor vouwen zou gelden is onbekend doch kan wellicht iets te maken hebben met de invloed van vitamine D op de vrouwelijke
hormonen.
Low Vitamin D Levels Associated With Chronic Pain In Women
Low vitamin D levels may contribute to chronic pain among women, suggests research published ahead of print in the Annals of the Rheumatic
Diseases.
The findings are based on the blood analyses and pain scores of almost 7000 45 year old men and women from across England, Scotland and Wales, all of whom were born during one week in March 1958.
Smokers, non-drinkers, the overweight and the underweight all reported higher rates of chronic pain.
The extent of chronic widespread pain did not vary among men according to vitamin D levels. However, this was not the case for women.
Women with vitamin D levels between 75 and 99 mmol/litre had the lowest rates of this type of pain, at just over 8%.
Women with levels of less than 25 mmol/litre had the highest rates, at 14.4%.
There appeared to be a J shaped curve, with the prevalence of widespread pain at 10% or higher among those with vitamin D levels above 99
mmol/litre.
The findings were not explained by gender differences in lifestyle or social factors, such as levels of physical activity and time spent outdoors, say the
authors.
And at the age of 45, few of the women would have entered the menopause, a period during which bone mineral density falls as oestrogen levels dwindle.
But by way of possible explanations, the authors point to osteomalacia, a disease of extreme vitamin D deficiency, which is associated with isolated or generalised bone pain. The hormonally active form of vitamin D is also involved in the regulation of immune system responses.
Around one in 10 of the population suffers from chronic widespread pain at any one time, say the
authors.
The causes are not fully understood, but social and psychological factors are known to affect the sensation and reporting of pain.
Vitamin D and chronic widespread pain in a white middle aged British population: evidence from a cross sectional population study
Online First AnnRheum Dis2008 doi: 10.1136/ard/2008.090456
Click here to view article online
Annals of The Rheumatic Rheumatic Diseases
Annals of the Rheumatic Diseases (ARD) is an international peer review journal committed to promoting the highest standards of scientific exchange and education. It covers all aspects of rheumatology, which includes the spectrum of musculoskeletal conditions, arthritic disease, and connective tissue disorders. ARD publishes basic, clinical, and translational scientific research. Concise scientific communication is encouraged and peer reviewed proceedings of international meetings are featured. Educational papers include state of the art reviews, "how to" articles and educational cases that focus on problems faced in clinical practice. The journal was first published in 1939 and has an authorative global Editorial Board and a growing international
readership.
The Rheumatic Rheumatic Diseases (September
2008)
