Eieren belangrijk bij een koolhydraatarmdieet om af te vallen*
Mensen met overgewicht die willen afvallen door een koolhydraatarmdieet kunnen het beste iedere dag 3
eieren eten, hierdoor verhoogt het goede cholesterol
(HDL), worden ontstekingsmarkers duidelijk verlaagd en wordt de insuline gevoeligheid duidelijk verbeterd. Dit blijkt uit een kleine studie onder 31 mannen met overgewicht die 12 weken lang een koolhydraatarmdieet met of zonder 3 eieren per dag kregen. Het cholesterol en de
luteïne in de eieren blijken hiervoor verantwoordelijk te zijn.
Eggs modulate the inflammatory response to carbohydrate restricted diets in overweight men
Joseph C Ratliff , Gisella Mutungi , Michael J Puglisi , Jeff S Volek and Maria Luz Fernandez
Nutrition & Metabolism 2008, 5:6doi:10.1186/1743-7075-5-6
Abstract (provisional)
Background
Carbohydrate restricted diets (CRD) consistently lower glucose and insulin levels and improve atherogenic dyslipidemia [decreasing triglycerides and increasing HDL cholesterol (HDL-C)]. We have previously shown that male subjects following a CRD experienced significant increases in HDL-C only if they were consuming a higher intake of cholesterol provided by eggs compared to those individuals who were taking lower concentrations of dietary cholesterol. Here, as a follow up of our previous study, we examined the effects of eggs (a source of both dietary cholesterol and lutein) on adiponectin, a marker of insulin sensitivity, and on inflammatory markers in the context of a CRD.
Methods
Twenty eight overweight men [body mass index (BMI) 26-37 kg/m2] aged 40-70 y consumed an ad libitum CRD (% energy from CHO:fat:protein = 17:57:26) for 12 wk. Subjects were matched by age and BMI and randomly assigned to consume eggs (EGG, n=15) (640 mg additional cholesterol/day provided by eggs) or placebo (SUB, n=13) (no additional dietary cholesterol). Fasting blood samples were drawn before and after the intervention to assess plasma lipids, insulin, adiponectin and markers of inflammation including C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-I+/-), interleukin-8 (IL-8), monocyte chemoattractant protein-1 (MCP-1), intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1(VCAM-1).
Results
Body weight, percent total body fat and trunk fat were reduced for all subjects after 12 wk (P < 0.0001). Increases in adiponectin were also observed (P < 0.01). Subjects in the EGG group had a 21% increase in this adipokine compared to a 7% increase in the SUB group (P < 0.05). Plasma CRP was significantly decreased only in the EGG group (P < 0.05). MCP-1 levels were decreased for the SUB group (P< 0.001), but unchanged in the EGG group. VCAM-1, ICAM-1, TNF-alpha and IL-8 were not modified by CRD or eggs.
Conclusions
A CRD with daily intake of eggs decreased plasma CRP and increased plasma adiponectin compared to a CRD without eggs. These findings indicate that eggs make a significant contribution to the anti-inflammatory effects of CRD, possibly due to the presence of cholesterol, which increases HDL-C and to the antioxidant lutein which modulates certain inflammatory
responses.
The complete article is available as a provisional PDF. The fully formatted PDF and HTML versions are in
production. (April
2008)
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