Westers dieet verhoogt kans op borstkanker.*
Uit een analyse van Chinese vrouwen met borstkanker blijkt dat een meer westers dieet de kans op borstkanker flink doet verhogen. Omdat in Shanghai steeds een meer westers dieet invoering vindt keken onderzoekers naar de gevolgen hiervan op het ontstaan van borstkanker. Ze vergeleken vrouwen met nog een chinees dieet van veel groenten, soja en zoetwater vis en vrouwen met een meer westers dieet van vlees, vooral varkens en rund, garnalen, zeevis, suikers, zuivel, brood en toetjes. De kans op borstkanker bij de vrouwen met een meer westers dieet en overgewicht (wellicht door dit dieet) hadden veel grotere kans op borstkanker tot zelfs ruim twee keer zo hoog op hormoongevoelige borstkanker.
Western Style 'Meat-Sweet' Diet Raises Breast Cancer Risk In Postmenopausal Chinese Women
A new study finds that the more "western" the diet -- marked by red meat, starches and sweets -- the greater the risk for breast cancer among postmenopausal Chinese women. According to researchers who conducted the analysis at Fox Chase Cancer Center in Philadelphia, Harvard University, Shanghai Cancer Institute, and Vanderbilt University, the findings mark the first time a specific association between a western diet and breast cancer has been identified in Asian
women.
The study, published in the issue of Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research, is the latest set of findings derived from the Shanghai Breast Cancer Study, conducted in the 1990s by Wei Zheng, M.D., Ph.D., M.P.H, and colleagues at Vanderbilt University. The Fox Chase researchers identified dietary habits among women in the study based on their reported eating habits, classifying them as either "meat-sweet" or
"vegetable-soy" eaters.
"The Shanghai data gave us a unique look at a population of Chinese women who were beginning to adopt more western-style eating habits," said, Marilyn Tseng, Ph.D. associate member in the population science division at Fox Chase. "We found an association between a western-style diet and breast cancer was pronounced in postmenopausal women, especially heavier women with estrogen receptor-positive tumors."
Breast cancers marked by the excessive production of estrogen receptors (ER+ breast cancers) form the majority of breast cancers and are often associated with obesity. According to Tseng, there seems to be a specific interaction between obesity and western cuisine among postmenopausal women that drives breast cancer, although the study did not offer a specific mechanism.
Tseng and her colleagues examined cases of women from the Shanghai Breast Cancer Study, 25 to 64 years of age, who were newly diagnosed with breast cancer from August 1996 to March 1998. Controls were selected from the Shanghai Resident Registry of permanent residents in urban Shanghai.
Through in-person interviews with the Shanghai study participants and residents of Shanghai, researchers established the existence of two primary dietary patterns - a"meat-sweet" diet and a "vegetable-soy" diet. The "meat-sweet" diet is characterized by various meats, primarily pork but also poultry, organ meats, beef and lamb, and shrimp, saltwater fish, and shellfish, as well as candy, dessert, bread, and milk. The "vegetable-soy" pattern is associated with various vegetables, soy-based products, and freshwater
fish.
Of 1,602 breast cancer cases identified during the study period, in-person interviews were completed for 1,459 (91.1%). In-person interviews were completed for 1,556 (90.3%) of the 1,724 control group
participants.
The "meat-sweet" pattern was significantly associated with increased risk of breast cancer among overweight postmenopausal women. Specifically, high intake of the "meat-sweet" pattern was associated with a greater than twofold increased risk of ER+ breast cancer among these women. The results showed no overall association of breast cancer risk with the "vegetable-soy" pattern.
"Our study suggests the possibility that the "meat-sweet" pattern interacts with obesity to increase breast cancer risk," Tseng said. "Low consumption of a western dietary pattern plus successful weight control may protect against breast cancer in a traditionally low-risk Asian population that is poised to more broadly adopt foods characteristic of western societies."
This research was funded through grants from the National Institutes of Health, the American Cancer Society, and the Commonwealth of Pennsylvania.
Tseng's co-authors include Xiaohui Cui from the Department of Epidemiology of the Harvard School of Public Health, Yu-Tang Gao from the Shanghai Cancer Institute, and Qi Dai, Xiao-Ou Shu, and Wei Zheng from the School of Medicine, and the Vanderbilt-Ingram Cancer Center at Vanderbilt
University.
The mission of the American Association for Cancer Research is to prevent and cure cancer. Founded in 1907, AACR is the world's oldest and largest professional organization dedicated to advancing cancer research. The membership includes nearly 26,000 basic, translational, and clinical researchers; health care professionals; and cancer survivors and advocates in the United States and more than 70 other countries. AACR marshals the full spectrum of expertise from the cancer community to accelerate progress in the prevention, diagnosis and treatment of cancer through high-quality scientific and educational programs. It funds innovative, meritorious research grants. The AACR Annual Meeting attracts more than 17,000 participants who share the latest discoveries and developments in the field. Special Conferences throughout the year present novel data across a wide variety of topics in cancer research, treatment, and patient care. AACR publishes five major peer-reviewed journals: Cancer Research; Clinical Cancer Research; Molecular Cancer Therapeutics; Molecular Cancer Research; and Cancer Epidemiology, Biomarkers & Prevention. Its most recent publication, CR, is a magazine for cancer survivors, patient advocates, their families, physicians, and scientists. It provides a forum for sharing essential, evidence-based information and perspectives on progress in cancer research, survivorship, and advocacy.
(Augustus 2007)
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