Prostaatkanker en gewicht?*
Het risico op dood gaan aan prostaatkanker is veel hoger als men een duidelijk overgewicht heeft. Daarentegen is er geen verband tussen het ontstaan van prostaatkanker en overgewicht. Dit blijkt uit een nieuwe grootschalige Amerikaanse studie. Bijna 230.000 mannen in de leeftijd van 50-70 jaar werden gevolgd. Mannen met een BMI van 25-30 hadden 25% meer kans op doodgaan aan prostaatkanker. Mannen met een BMI van 30-35 hadden 46% meer kans en zij met een hogere BMI dan 35 hadden zelfs 100% meer kans.
Risk
Of Dying From Prostate Cancer Increased By Excess Weight And Adult Weight Gain
A
new study finds that obesity increases the risk of death from prostate cancer,
even though it does not increase the overall risk a man will be diagnosed with
the disease. Published in the February 15, 2007 issue of CANCER, a
peer-reviewed journal of the American Cancer Society, the study reveals that
higher body mass index (BMI) and weight gain in adulthood correlated strongly
with increased risk of death from prostate cancer. However, no such association
was found between BMI or weight gain and the development of the cancer. The
study is the first large, prospective study to identify increasing weight after
age 18 as an independent, poor prognostic factor for prostate cancer.
The incidence of obesity has increased dramatically worldwide. In the U.S., for
example, the number of states reporting obesity rates greater than 20 percent
increased from zero in 1985 to 46 in 2005. Today, 30 percent of American adults
are categorized as obese - i.e., a BMI greater than 30. Obesity is linked to
chronic medical problems, including heart disease, diabetes, gallbladder disease,
and stroke. In addition, studies indicate higher BMIs are linked to some cancers,
including breast and colorectal cancer.
The influence of obesity and weight gain on the development of localized and
aggressive forms of prostate cancer is not clear. A recent meta-analysis
suggested only a weak correlation between obesity and prostate cancer incidence.
However, clinical studies have suggested that men with higher BMI or men who
gained weight most rapidly since age 25 were at greater risk of treatment
failure or being diagnosed with advanced disease.
Led by Margaret E. Wright, Ph.D., of the Division of Cancer Epidemiology and
Genetics at the National Cancer Institute in Bethesda, MD, researchers followed
287,760 men, ages 50-71 years as part of the NIH-AARP Diet and Health Study to
examine the individual impact of BMI and adult weight change on the incidence,
severity and outcome of prostate cancer.
The researchers found that higher BMI and weight gain since the age of 18 were
associated with significantly higher risk of death from prostate cancer. As BMI
increased, so did the relative risk of death. Men who were overweight (BMI
25-29.9) had a 25 percent higher risk, mildly obese men (BMI 30-34.9) had a 46
percent higher risk, and severely obese men (BMI greater than 35) had a 100
percent, or doubled risk. Similarly, men who gained weight since the age of 18
were also at increased risk of a fatal outcome. Neither overweight nor obesity,
however, was associated with developing prostate cancer.
That obesity did not impact the incidence of prostate cancer is consistent with
findings from most other studies. However, that "BMI and adult weight gain
were each linked with higher prostate cancer mortality," significantly
links "adiposity to prostate cancer progression leading to death,"
conclude the authors.
###
Article: "Prospective Study of Adiposity and Weight Change in Relation to
Prostate Cancer Incidence and Mortality," Margaret E. Wright, Shih-Chen
Chang, Arthur Schatzkin, Demetrius Albanes, Victor Kipnis, Traci Mouw, Paul
Hurwitz, Albert Hollenbeck, Michael F. Leitzmann, CANCER; Published
Online: January 15, 2007 (DOI: 10.1002/cncr.22443); Print Issue Date: February
15, 2007. (Jan. 2007) (Opm.
Hier kunt u uw BMI berekenen.)