Aspirine
en osteoporose*
Uit een studie, weliswaar met muizen, blijkt dat aspirine in lage doseringen
goed kan zijn bij osteoporose. In de studie bleek aspirine de
activiteiten van
cellen die voor botafbraak zorgen te verminderen en juist de activiteit van
cellen die zorgen voor de botopbouw te activeren. Het resultaat was dat de muizen
dikkere en sterkere botten kregen.
Aspirin may be useful for osteoporosis
In an animal study of osteoporosis, researchers have shown that low-dose aspirin
can decrease the activity of cells that breakdown bone, while increasing the
activity of cell that build up bone, according to research published online in
the journal PLoS One.
Increased activity of cells that breakdown bone is typically cited as the cause
of osteoporosis, but recent evidence suggests that a drop in bone-forming cells
may also play a role, Dr. Songtao Shi from University of Southern California
School of Dentistry, Los Angeles, and colleagues note.
In lab studies, the team found that aspirin reduced the destruction of
bone-forming cells in mice. They further showed that adding low-dose aspirin
makes bone-forming cells more active and bone-degrading cells less active,
resulting in thicker and stronger bones.
"Aspirin may offer a new approach" for treating the osteoporosis
commonly seen in postmenopausal women, the researchers conclude.
Although human studies have suggested that regular use of aspirin may have a
moderate beneficial effect on bone thickness in postmenopausal women, "more
detailed studies are necessary to (clarify) the underlying mechanism by which
aspirin may prevent and treat osteoporosis," Shi added in comments.
SOURCE: PLoS One 2008. (Augustus
2008)
