Teveel calcium en uw hart*
Eerdere studies hebben al laten zien dat extra calcium supplementen niet goed voor het hart kunnen zijn
en uit deze grote Zweedse studie blijkt dat nu duidelijk. In de studie werden ruim 61.000 vrouwen gemiddeld 19 jaar lang gevolgd. In die 19 jaar was 17% van de vrouwen gestorven, waarvan 48% aan een hart- of vaatziekte en 8% aan een beroerte. Zij die 1.400 mg of meer
calcium per dag met voeding en als supplement innamen hadden twee keer zoveel kans om dood te gaan dan zij die 600 tot 1.000 mg per dag innamen. Dagelijks minder dan 600 mg bleek ook
een iets verhoogd risico te geven.
Risk of Cardiovascular Death Doubled in Women With High Calcium Intake: High Risk Only in Those Taking Supplements as Well
High intakes of calcium (corresponding to diet and supplements) in women are associated with a higher risk of death from all causes, but cardiovascular disease in particular, compared with women with lower calcium intake, a new study suggests.
Experts recommend a high calcium intake (as it plays a pivotal role in human physiology) and as such, more than 60% of middle-aged and older women in the USA now take supplements.
However, recent trials have indicated a higher risk of ischemic heart disease and stroke with calcium supplements but this was not observed in another trial and few studies have examined this association.
Researchers from Uppsala University in Sweden therefore studied 61,443 Swedish women (born between 1914 and 1948) for an average of 19 years to test this association.
Data were taken from the Swedish Cause of Death Registry and data on diet were taken from the Swedish Mammography Cohort. Total calcium intake included supplemental calcium. The mean intake in the lowest quartile was 572mg/day (the equivalent of five slices of cheese ) and in the highest 2137mg/day.
Information was obtained from the women on menopausal status, postmenopausal estrogen therapy, parity information, weight and height, smoking habits, leisure-time physical activity and educational level.
Results showed that during 19 years of follow-up, 11,944 women (17%) died: 3,862 of these (32%) died from cardiovascular disease, 1932 (16%) heart disease and 1100 (8%) from stroke. Highest rates of all-cause, cardiovascular and heart disease were observed among those with a dietary calcium intake higher than 1400mg/day.
In addition, researchers observed higher death rates among women with an intake below 600mg/day.
Women who had a higher dietary intake of calcium exceeding 1400mg/day and also used supplements had a higher death rate compared to those not taking supplements. Women with a high dietary calcium intake (>1400 mg/day) were more than twice as likely to die compared with women with a 600-999mg/day calcium intake.
The researchers explain their findings by suggesting that diets very low or very high in calcium can override normal homeostatic control causing changes in blood levels of calcium.
The researchers conclude that high calcium is associated with "higher all-cause and cardiovascular mortality rates" and so to prevent fractures in the elderly emphasis should be placed on individuals with a low intake of calcium rather than increasing the intake of those already consuming satisfactory amounts.
De volledige studie.
(Maart 2013)
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