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Kurkuma en hartoperaties*
Uit een kleine Thaise studie onder 121 patiënten die een bypassoperatie ondergingen blijkt dat het kruid kurkuma de kans op een hartaanval flink kan verminderen. Het is bekend dat een hartaanval na een bypassoperatie de kans op succes sterk verminderd, ook is het bekend dat de bioactieve stof curcumine in kurkuma goede ontstekingsremmende eigenschappen heeft. In de studie kregen de deelnemers of een placebo of kurkuma. Vanaf drie dagen voor de operatie 4 gram/dag en dat tot 5 dagen na de operatie. Na afloop bleken de patiënten in de kurkumagroep wel 65% minder kans te hebben op een hartaanval dan zij in de placebogroep. Zij hadden ook duidelijk minder ontstekingsmarkers in hun bloed.
Effects of Curcuminoids on Frequency of Acute Myocardial Infarction After Coronary Artery Bypass Grafting
· Wanwarang Wongcharoen, MD · Sasivimon Jai-aue, MD · Arintaya Phrommintikul, MD · Weerachai Nawarawong, MD · Surin Woragidpoonpol, MD · Thitipong Tepsuwan, MD · Apichard Sukonthasarn, MD · Nattayaporn Apaijai, BSc · Nipon Chattipakorn, MD, PhD
It is well established that myocardial infarction (MI) associated with coronary artery bypass grafting (CABG) predicts a poor outcome. Nevertheless, cardioprotective therapies to limit myocardial injury after CABG are lacking. Previous studies have shown that curcuminoids decrease proinflammatory cytokines during cardiopulmonary bypass surgery and decrease the occurrence of cardiomyocytic apoptosis after cardiac ischemia/reperfusion injury in animal models. We aimed to evaluate whether curcuminoids prevent MI after CABG compared to placebo. The 121 consecutive patients undergoing CABG were randomly allocated to receive placebo or curcuminoids 4 g/day beginning 3 days before the scheduled surgery and continued until 5 days after surgery. The primary end point was incidence of in-hospital MI. The secondary end point was the effect of curcuminoids on C-reactive protein, plasma malondialdehyde, and N-terminal pro–B-type natriuretic peptide levels. Baseline characteristics were comparable between the curcuminoid and placebo groups. Mean age was 61 ± 9 years. On-pump CABG procedures were performed in 51.2% of patients. Incidence of in-hospital MI was decreased from 30.0% in the placebo group to 13.1% in the curcuminoid group (adjusted hazard ratio 0.35, 0.13 to 0.95, p = 0.038). Postoperative C-reactive protein, malondialdehyde, and N-terminal pro–B-type natriuretic peptide levels were also lower in the curcuminoid than in the placebo group. In conclusion, we demonstrated that curcuminoids significantly decreased MI associated with CABG. The antioxidant and anti-inflammatory effects of curcuminoids may account for their cardioprotective effects shown in this study. (April 2012)