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Koffie geeft duidelijk lagere kans op baarmoederkanker*
Uit een Amerikaanse studie onder ruim 67.000 vrouwen van 34 tot 59 jaar die 26 jaar gevolgd werden blijkt dat het dagelijks drinken van koffie de kans op baarmoederkanker duidelijk kan verminderen. Vrouwen die vier of meer koppen koffie per dag dronken hadden 25% minder kans op baarmoederkanker dan zij die weinig tot geen koffie dronken. Twee koppen per dag gaf 7% minder kans. Het drinken van 2 of meer koppen deca per dag gaf 22% minder kans. Geen relatie werd gevonden tussen het drinken van thee en baarmoederkanker. Uit eerdere onderzoeken is al gebleken dat koffie de bloedwaarden insuline en oestrogeen doet verlagen. Een te veel van deze hormonen wordt in verband gebracht met baarmoederkanker. Alhoewel het onderzoek geen directe oorzaak laat zien tussen de koffie en de kanker, sluiten de onderzoekers een oorzakelijke verband niet uit omdat koffie veel antioxidanten bevat, meer dan heel wat groenten- en fruitsoorten.
A Prospective Cohort Study of Coffee Consumption and Risk of Endometrial Cancer over a 26-Year Follow-Up
1. Youjin Je1, 2. Susan E. Hankinson2,3, 3. Shelley S. Tworoger2,3, 4. Immaculata DeVivo2,3, and 5. Edward Giovannucci1,2,3
+ Author Affiliations
1. Authors' Affiliations: Departments of 1Nutrition and 2Epidemiology, Harvard School of Public Health; and 3Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 
1. Corresponding Author:
Youjin Je, Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115; Fax: 617-432-2435; E-mail: yje@hsph.harvard.edu
Abstract
Background: Coffee has been reported to lower levels of estrogen and insulin, two hormones implicated in endometrial carcinogenesis, but prospective data on the relation between coffee consumption and risk of endometrial cancer are limited. 
Methods: We prospectively assessed coffee consumption in relation to endometrial cancer risk in the Nurses' Health Study (NHS) with 67,470 female participants aged 34 to 59 in 1980. Cumulative average coffee intake was calculated with all available questionnaires to assess long-term effects. Cox regression models were used to calculate incidence rate ratios (RR), controlling for other risk factors. 
Results: Fewer than 4 cups of coffee per day were not associated with endometrial cancer risk. However, women who consumed 4 or more cups of coffee had 25% lower risk of endometrial cancer than those who consumed less than 1 cup per day (multivariable RR = 0.75; 95% CI = 0.57–0.97; Ptrend = 0.02). We found the similar association with caffeinated coffee consumption (RR for ≥4 vs. <1 cup/d = 0.70; 95% CI = 0.51–0.95). For decaffeinated coffee consumption, a suggestive inverse association was found among women who consumed 2 or more cups per day versus <1 cup/mo. Tea consumption was not associated with endometrial cancer risk. 
Conclusions: These prospective data suggest that four or more cups of coffee per day are associated with a lower risk of endometrial cancer. 
Impact: Drinking of coffee, given its widespread consumption, might be an additional strategy to reduce endometrial cancer risk. However, addition of substantial sugar and cream to coffee could offset any potential benefits. Cancer Epidemiol Biomarkers Prev; 20(12); 2487–95. ©2011 AACR. (December 2011)