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Kurkuma en zwarte peper voor gezonde slagaders*
Uit een studie met ratten blijkt dat extra voeding met kurkuma of zwarte peper veranderingen aan de slagaders als gevolg van hoge bloeddruk teniet kunnen doen. Kurkuma lijkt ook nog voor een duidelijk lagere bloeddruk te kunnen zorgen. In de studie kregen de ratten een middel toegediend waardoor ze hoge bloeddruk kregen. Door hoge bloeddruk treden er veranderingen op in de wanden van de slagaders. De bioactieve stof peperine uit zwarte peper en meer nog curcumine uit kurkuma in het drinkwater zorgden voor het tegengaan van die veranderingen in de slagaders. Kurkuma zorgde ook nog eens dat de bloeddruk weer flink daalde.
Spice up the hypertension diet - curcumin and piperine prevent remodeling of aorta in experimental L-NAME induced hypertension
Livia Hlavackova, Andrea Janegova, Olga Ulicna, Pavol Janega, Andrea Cerna and Pavel Babal 
Nutrition & Metabolism 2011, 8:72 doi:10.1186/1743-7075-8-72
abstract (provisional)
Background
Increase of blood pressure is accompanied by functional and morphological changes in the vascular wall. The presented study explored the effects of curcuma and black pepper compounds on increased blood pressure and remodeling of aorta in the rat model of experimental NO-deficient hypertension. 
Methods
Wistar rats were administered for 6 weeks clear water or L-NAME (40 mg/kg/day) dissolved in water, piperine (20 mg/kg/day), curcumin (100 mg/kg/day) or their combination in corn oil by oral gavage. The systolic blood pressure was measured weekly. Histological slices of thoracic aorta were stained with hematoxylin and eosin, Mallory's phosphotungstic acid hematoxylin (PTAH), orcein, picrosirius red and van Gieson staining and with antibodies against smooth muscle cells actin. Microscopic pictures were digitally processed and morphometrically evaluated. 
Results
The increase of blood pressure caused by L-NAME was partially prevented by piperine and curcumin, but the effect of their combination was less significant. Animals with hypertension had increased wall thickness and cross-sectional area of the aorta, accompanied by relative increase of PTAH positive myofibrils and decrease of elastin, collagen and actin content. Piperine was able to decrease the content of myofibrils and slightly increase actin, while curcumin also prevented elastin decrease. The combination of spices had similar effects on aortic morphology as curcumin itself. 
Conclusions
Administration of piperine or curcumin, less their combination, is able to partially prevent the increase of blood pressure caused by chronic L-NAME administration. The spices modify the remodeling of the wall of the aorta induced by hypertension. Our results show that independent administration of curcumin is more effective in preventing negative changes in blood vessel morphology accompanying hypertensive disease. 
De volledige studie. (November 2011) 

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