Frambozen tegen leverontstekingen en kanker*
Uit een studie, weliswaar met ratten blijkt dat frambozen goed werkzaam kunnen zijn tegen
leverontstekingen en leverkanker.
Fresh raspberry phytochemical extract inhibits hepatic lesion in a Wistar rat model
Yan Liu , Ming Liu , Bin Li , Jin-Lu Zhao , Chun-Peng Zhang , Luo-Qiang Lin , Hong-Sheng Chen , Shu-Jun Zhang , Jun-Chao Jin , Lei Wang , Le-Jing Li and Jia-Ren Liu
Nutrition & Metabolism 2010, 7:84doi:10.1186/1743-7075-7-84
Abstract
Background
Red raspberry possesses potent antioxidant capacity and antiproliferative activity against cancer in vitro.
Methods
The objective of this study was to determine the protective effects of raspberry 80% acetone extract in a rat hepatic lesions model induced by diethylnitrosamine (DEN). Rats were treated with the red raspberry extract (0.75, 1.5 or 3.0 g/kg of body weight) by gavage starting 2 h after DEN administration and continuing for 20 weeks.
Results
A dose-dependent inhibition by red raspberry extract of DEN-induced hepatic nodule formation which stands for hepatic lesions was observed. Corresponding hepatic nodule incidence rates were 45.0, 40.0, 25.0 and 5.0% in positive control, low, middle and high groups, respectively (P < 0.01 or 0.05). Gross findings, histopathological and ultrastructural evaluations of hepatic lesion were performed on 9, 8, 5 and 1 hepatic burdened nodules in positive control, low, middle and high groups, respectively, identified in rats from the respective groups of 20. A decreasing trend of proportions of hepatocellular carcinoma masses accompanied the increasing doses of red raspberry extract.
Conclusions
These findings demonstrate that the potent capacity of red raspberry diet could not only suppress DEN-induced hepatic lesions in rats, but also reduce the definite diagnostic features of neoplasm.
Het arikel.
(December 2010)
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