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Opsporen zwangerschapsdiabetes kan eenvoudiger*
Volgens Canadese wetenschappers kan het opsporen van zwangerschapsdiabetes sterk vereenvoudigen. Een buikomtrek van meer dan 85 cm én een verhoogde bloedwaarden triglyceriden in het bloed (meer dan 1,7 mmol/l = 150 mg/dl) tijdens het eerste trimester van de zwangerschap, verhoogt zeer sterk de kans om later in de zwangerschap diabetes te krijgen. Bij vrouwen die wel een buikomtrek van meer dan 85 cm hadden, maar zonder verhoogde triglyceridenwaarden, was het risico op zwangerschapsdiabetes niet verhoogd. 
The "hypertriglyceridemic waist" phenotype and glucose intolerance in pregnancy
Diane Brisson, PhD, Patrice Perron, MD MSc, Simon-Pierre Guay, BSc, Daniel Gaudet, MD PhD and Luigi Bouchard, PhD MBA 
From the Department of Medicine, Université de Montréal, ECOGENE-21 and Lipid Clinic (Brisson, Perron, Guay, Gaudet, Bouchard), Chicoutimi Hospital, Saguenay, Que.; and the Department of Medicine (Perron), Université de Sherbrooke, Sherbrooke, Que. 
Correspondence to: Dr. D. Brisson, ECOGENE-21, Université de Montréal, Chicoutimi Hospital, 225 St-Vallier, Chicoutimi QC G7H 7P2; diane.brisson@ecogene21.org
Background: Abdominal visceral adiposity in early pregnancy has been associated with impaired glucose tolerance in later pregnancy. The "hypertriglyceridemic waist" phenotype (i.e., abdominal obesity in combination with hyper-triglyceridemia) is a clinical marker of visceral obesity. Our study aimed to assess the association between the hyper-triglyceridemic-waist phenotype in early pregnancy and glucose intolerance in later pregnancy. 
Methods: Plasma triglycerides and waist girth were measured at 11-14 weeks of gestation among 144 white pregnant women. Glycemia was measured following a 75-g oral glucose tolerance test performed at 24-28 weeks of gestation. 
Results: A waist girth greater than 85 cm in combination with a triglyceride level 1.7 mmol/L in the first trimester was associated with an increased risk of two-hour glucose 7.8 mmol/L following the 75-g oral glucose tolerance test (odds ratio [OR] 6.1, p = 0.002). This risk remained significant even after we controlled for maternal age, fasting glucose at first trimester and previous history of gestational diabetes (OR 4.7, p = 0.02). 
Interpretation: Measurement of waist girth in combination with measurement of triglyceride concentrations in the first trimester of pregnancy could improve early screening for gestational glucose intolerance. (Oktober 2010)