Perziken en pruimen bij borstkanker*
Uit een studie weliswaar in het laboratorium met weefsels, blijkt dat extracten van
perziken en pruimen borstkankercellen, zelfs de meest agressieve kan vernietigen terwijl gezonde cellen onaangeroerd
blijven. Het blijken vooral de bioactieve stoffen als chlorogeenzuur en neochlorogeenzuur in het (steen)fruit
die hiervoor verantwoordelijk zijn. Inmiddels hebben de onderzoekers ook bij proeven met dieren vergelijkbare resultaten gevonden.
Breast cancer cells destroyed by peach and plum extracts
Even the most aggressive types of breast cancer cells couldn't stand up to treatments with peach and plum extracts. That's the outcome of a natural fruit-derived treatment tested in the Texas AgriLife Research Lab which resulted in cancer cells dying while normal cells were not harmed at all.
"It was a differential effect which is what you're looking for because in current cancer treatment with chemotherapy, the substance kills all cells, so it is really tough on the body," Dr. David Byrne, an AgriLife Research plant breeder and scientist, said in a press statement. "Here, there is a five-fold difference in the toxic intensity. You can put it at a level where it will kill the cancer cells -- the very aggressive ones -- and not the normal ones."
So what could be in peaches and plums (fruits known as "stone" fruits because of their large, stone-like seeds) that zaps even the most deadly breast cancer cells? In their study, which was published in the Journal of Agriculture and Food Chemistry , Dr. Byrne and fellow AgriLife food scientist Dr. Luis Cisneros-Zevallos concluded two phenolic compounds were responsible for the cancer cell deaths.
Phenols are organic compounds that occur in fruits. Slightly acidic, phenols are associated with the color, smell and taste of specific fruits. In a statement to the media, Dr. Cisneros-Zevallos explained that two specific phenolic acid components -- known as chlorogenic and neochlorogenic compounds -- were responsible for killing the breast cancer cells in the AgriLife study. Although very common in fruits, stone fruits such as plums and peaches are especially rich in these types of
phenols.
In addition to their successful research showing the stone fruit phenols killed breast cancer cells, the research team also found that animal studies provided even more evidence that the fruit extracts have power anti-cancer properties. The compounds prevented cancer from growing in animals given the fruit treatments.
Identifying peach and plum polyphenols with chemopreventive potential against estrogen-independent breast cancer cells.
Noratto G, Porter W, Byrne D, Cisneros-Zevallos L.
Department of Horticultural Sciences and Vegetable and Fruit Improvement Center, Texas A&M University, College Station, Texas 77843, USA.
Abstract
Our objective was to evaluate the cancer suppression activity of extracts from a commercial variety of yellow-fleshed peach 'Rich Lady' (RL) and a red-fleshed plum 'Black Splendor' (BS) and identify the phenolic fractions that may possess potential as chemopreventive and/or chemotherapeutic natural compounds. The peach RL extract effectively inhibited the proliferation of the estrogen-independent MDA-MB-435 breast cancer cell line. The concentration to inhibit 50% of cell proliferation (IC(50)) was approximately 42 mg/L for this cell line compared to an IC(50) of approximately 130 and approximately 515 mg/L for the noncancerous breast cell line MCF-10A and the estrogen-dependent breast cancer cell line MCF-7, respectively. Similarly, BS extracts showed greater effects on MDA-MB-435 cells as compared to the other breast cancer or the normal breast cell lines. In general, BS extracts were less effective than RL extracts. Within all RL and BS fractions, fraction 3 (F3, flavonoids) and fraction 4 (F4, procyanidins) were more potent than fraction 1 (F1, phenolic acids) and fraction 2 (F2, anthocyanins) against the three cell lines. The order of potency of RL fractions against MDA-MB-435 was F(3) approximately F(4) > F(1) > F(2). The antiproliferative activity of pure compounds identified in F(3) and F(1) confirmed that quercetin 3beta-glucoside is the bioactive compound in F(3), with the same level of toxicity on the estrogen-independent MDA-MB-435 breast cancer and breast epithelial MCF-10A cells (IC(50) = 1.9 +/- 0.2 and 1.8 +/- 0.3, respectively). However, we confirmed that phenolic acids present in F(1): chlorogenic and neo-chlorogenic acids have potential as chemopreventive dietary compounds because of the relatively high growth inhibition exerted on the estrogen-independent MDA-MB-435 breast cancer cell line and low toxicity exerted in the normal MCF-10A cells.
PMID: 19530711 (Augustus 2010)
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