Vitamine D tegen aderverkalking*
Uit een Amerikaanse studie onder 1.730 deelnemers blijkt dat bloedwaarden vitamine D in relatie staan tot de incidentie van calcificatie van de kransslagaders. Lage bloedwaarden geven een duidelijk hogere kans op calcificatie en daardoor op meer
aderverkalking van de slagaders.
25-Hydroxyvitamin D Levels Inversely Associate with Risk for Developing Coronary Artery Calcification
Ian H. de Boer*, , Bryan Kestenbaum*, , Abigail B. Shoben , Erin D. Michos , Mark J. Sarnak|| and David S. Siscovick*
*Department of Medicine,
Division of Nephrology, and
Department of Biostatistics, University of Washington, Seattle, Washington;
Department of Medicine, Johns Hopkins University, Baltimore, Maryland; and
||Department of Medicine, Division of Nephrology, Tufts Medical Center, Boston, Massachusetts
Correspondence: Dr. Ian H. de Boer, Division of Nephrology, University of Washington, Box 356521, 1959 NE Pacific Street, Seattle, WA 98195. Phone: 206-616-5403; Fax: 206-685-2473; E-mail: deboer@u.washington.edu
Vitamin D deficiency associates with increased risk for cardiovascular events and mortality, but the mechanism driving this association is unknown. Here, we tested whether circulating 25-hydroxyvitamin D concentration associates with coronary artery calcification (CAC), a measure of coronary atherosclerosis, in the Multi-Ethnic Study of Atherosclerosis. We included 1370 participants: 394 with and 976 without chronic kidney disease (estimated GFR <60 ml/min per 1.73 m2). At baseline, CAC was prevalent among 723 (53%) participants. Among participants free of CAC at baseline, 135 (21%) developed incident CAC during 3 yr of follow-up. Lower 25-hydroxyvitamin D concentration did not associate with prevalent CAC but did associate with increased risk for developing incident CAC, adjusting for age, gender, race/ethnicity, site, season, physical activity, smoking, body mass index, and kidney function. Further adjustment for BP, diabetes, C-reactive protein, and lipids did not alter this finding. The association of 25-hydroxyvitamin D with incident CAC seemed to be stronger among participants with lower estimated GFR. Circulating 1,25-dihydroxyvitamin D concentrations among participants with chronic kidney disease did not significantly associate with prevalent or incident CAC in adjusted models.
In conclusion, lower 25-hydroxyvitamin D concentrations associate with increased risk for incident CAC. Accelerated development of atherosclerosis may underlie, in part, the increased cardiovascular risk associated with vitamin D
deficiency. (September
2009)
