Lijnzaad bij prostaatkanker*
Uit een studie onder 161 mannen met prostaatkanker blijkt dat
lijnzaad al dan niet gecombineerd met een vetarmdieet de vermenigvuldiging van kankercellen duidelijk doet afnemen. De mannen werden verdeeld in 4 groepen, zonder speciaal dieet, met alleen een vetarmdieet (< 20% vet van de totale calorie-inname), met een normaal dieet met extra lijnzaad of met een vetarmdieet met extra lijnzaad. De mate van vermenigvuldiging was resp. 3,23 , 2,56 , 1,66 en 1,50. Bij het normale dieet met lijnzaad dus bijna de helft en het vetarmdieet met lijnzaad ruim de helft minder vermenigvuldiging van de kankercellen.
Flaxseed Supplementation (Not Dietary Fat Restriction) Reduces Prostate Cancer Proliferation Rates In Men Presurgery
A multi-site randomized controlled trial to test the effects of low fat and /or flaxseed-supplemented diets is reported in Cancer Epidemiology, Biomarkers and Prevention. Flaxseed is an oilseed commonly consumed in the Middle Ages, and is not common in the modern era due to its short shelf life. Flaxseed is rich in dietary lignan, which has anti-mitotic, anti-angiogenesis, anti-oxidant and phytoestrogenic effects. It also reduces testosterone
-reductase.
A total of 161 men diagnosed with prostate cancer (CaP) and scheduled for radical prostatectomy at least 21 days after accrual were enrolled in the study. They were randomized into 4 groups - control (usual diet), flaxseed-supplemented (30gm/day), low-fat diet (<20% of energy from dietary fat), or flaxseed-supplemented plus low fat. Dietary questionnaires, serum and urine levels of relevant compounds and prostatectomy tissue were assessed. The primary study endpoint was proliferation index (by Ki-67 staining using the antibody MIB-1) in the prostatectomy tissue.
The dropout rate was 7.5%. Most participants had early stage CaP, and dietary logs revealed good to excellent adherence. Both erythrocytes and prostatic tissue had significantly higher levels of longer chained fatty acids. Tumor proliferation was significantly lower in the flaxseed-supplemented arm (proliferation index = 1.66), compared to 3.23 for controls, 2.56 for low-fat diet, and 1.50 for the combined flaxseed with low-fat diet. No differences were noted between groups for apoptosis, Gleason sum, or serum markers although serum PSA, testosterone, IFG-1, and IFGBP-3 decreased in all groups. Men in the low-fat diet group had significant reductions in body mass index and total and low-density lipoprotein cholesterol.
Demark-Wahnefried W, Polascik TJ, George SL, Switzer BR, Madden JF, Ruffin MT 4th, Snyder DC, Owzar K, Hars V, Albala DM, Walther PJ, Robertson CN, Moul JW, Dunn BK, Brenner D, Minasian L, Stella P, Vollmer RT.
Cancer Epidemiol Biomarkers Prev. 17(12):3577-87.
doi:10.1158/1055-9965.EPI-08-0008 Prev.17:3577-87
Written by UroToday.com Contributing Editor Christopher P. Evans, MD, FACS
UroToday - the only urology website with original content written by global urology key opinion leaders actively engaged in clinical practice.
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2009)
