Meer bijwerkingen bij gebruik osteoporose medicijn*
Bij de behandeling van osteoporose wordt vaak als medicijn een bisfosfonaat (Fosamax, Actonel, Aredia. Didronel en Zometa) voorgeschreven. Eerdere studies hebben al laten zien dat deze medicijnen nare bijwerkingen kunnen, zoals spierpijnen, hartritmestoornissen, gebroken dijbenen en ostonecrose (afsterven van botweefsel) van de kaak. Dit laatste zou zich vooral voordoen na injecties met bisfosfonaten. Uit een nieuwe studie nu blijkt dat deze ostonecrose zich vaker en wel in 4% van de gevallen voordoet. Uit een ander bericht door de Amerikaanse FDA (Food and Drug Administration), de instantie die de kwaliteit en veiligheid van voedsel en medicijnen bewaakt, wordt nu gewaarschuwd voor een verhoogde kans door deze medicijnen op slokdarmkanker.
Study Links Osteoporosis Drugs to Jaw Trouble
The proportion of people taking widely prescribed oral osteoporosis drugs who develop a nasty jaw condition may be much higher than previously thought, a new study suggests.
Previous reports had indicated that the risk of developing osteonecrosis of the jaw (ONJ) from bisphosphonates in pill form were "negligible," although there was a noted risk in people taking the higher-dose intravenous form of the drug.
But Dr. Parish Sedghizadeh, an assistant professor of clinical dentistry at the University of Southern California School of Dentistry in Los Angeles, said his clinic is seeing one to four new cases a week, compared to one a year in the past. This led him to investigate the phenomenon and publish the findings in the Journal of the American Dental Association.
"This is more frequent than everybody would like to think it is," said Sedghizadeh, lead author of the study.
ONJ is characterized by pain, soft-tissue swelling, infection, loose teeth and exposed bone.
Dr. James Liu, chairman of obstetrics and gynecology at MacDonald Women's Hospital at Case Medical Center, University Hospitals in Cleveland, said the finding "does not mean that women should stop taking the drug if they're on it. It does mean that there may be more frequent side effects than was previously known."
Bisphosphonates are medications used to reduce the risk of bone fracture and to increase bone mass in people with osteoporosis. They're also used to slow bone "turnover" in people who have cancer that has spread to their bones, and in people who have the blood cancer multiple myeloma.
Use of bisphosphonates has been associated with other problems in the past, including an increased risk of atrial fibrillation (a type of abnormal heart rhythm), unusual fractures of the thigh bone, and inflammatory eye disease.
After searching the USC School of Dentistry's electronic medical records database, the study authors found that nine of 208 patients taking Fosamax had active ONJ, a prevalence of about 4 percent. All were patients who had undergone some kind of dental procedure, such as having a tooth removed.
Fosamax (alendronate) is the most widely prescribed oral bisphosphonate and has been the 21st most prescribed drug in the United States since 2006, according to background information in the study.
The jaw complication has been seen in patients taking Fosamax for as little as one year. It seems to occur most frequently after routine tooth extraction, the study authors said.
Although no one is sure why bisphosphonates seem to have this effect only on jaw bones, Sedghizadeh speculated that the drugs may make it easier for bacteria to adhere to bone that is exposed after a tooth extraction.
Previously, experts had thought that ONJ in people taking intravenous bisphosphonates was related to their underlying condition (for example, cancer) than to the actual drug, Liu explained.
The USC School of Dentistry now screens every patient for bisphosphonate use.
"As a school now, we don't have complications any more, we only have referrals," Sedghizadeh said. "We put patients on anti-microbial, anti-fungal rinse one week pre-operatively or post-operatively. If they have been on bisphosphonates six months or a year or longer, then we have a prevention protocol which has been very, very effective."
According to a statement released by Merck & Co., which makes Fosamax, the new study "has material methodological flaws and scientific limitations, making it unreliable as a source for valid scientific conclusions regarding the prevalence of ONJ in patients taking alendronate."
No reports of ONJ have been noted in controlled trials involving more than 17,000 patients, the statement said.
More information
To learn more about ONJ, visit the American Dental Association.
SOURCES: Parish Sedghizadeh, DDS, MS, assistant professor of clinical dentistry, University of Southern California School of Dentistry, Los Angeles; James Liu, M.D., chairman, department of obstetrics and gynecology, MacDonald Women's Hospital at Case Medical Center, University Hospitals, Cleveland; Merck & Co. 2009, Journal of the American Dental Association
Osteoporosis drugs linked to esophageal cancer
Merck's (MRK.N: Quote, Profile, Research, Stock Buzz) popular osteoporosis drug Fosamax and other similar drugs may carry a risk for esophageal cancer, a U.S. Food and Drug Administration official said on Wednesday.
Diane Wysowski of the FDA's division of drug risk assessment said researchers should check into potential links between so-called bisphosphonate drugs and cancer.
In a letter in Thursday's New England Journal of Medicine, Wysowski said since the initial marketing of Fosamax, known generically as alendronate, in 1995, the FDA has received 23 reports in which patients developed esophageal tumors.
Typically, two years lapsed between the start of the drug and the development of esophageal cancer. Eight patients died, she reported.
In Europe and Japan, 21 cases involving Fosamax have been logged, as well as six instances where Procter & Gamble's (PG.N: Quote, Profile, Research, Stock Buzz) Actonel or risedronate and Didronel or etidronate, and Roche's (ROG.VX: Quote, Profile, Research, Stock Buzz) Boniva or ibandronate may have been involved. Six of those people died.
Esophagitis, which is an inflammation of the lining of the tube carrying food to the stomach, is already know to be a side effect of the drugs, which is why patients are instructed to remain upright for at least a half hour after taking them.
In addition, Wysowski said, doctors should avoid prescribing the drugs to people with Barrett's esophagus, which is a change in the lining that leads to the stomach. It is often found in people with acid reflux disease and itself increases the risk of cancer.
In November the FDA said clinical trial data showed no overall risk of heart rhythm problems in patients taking bisphosphonates.
However, the FDA also said it was aware of conflicting findings in other studies and was considering whether conducting further studies to investigate the risk were feasible.
The drugs aim to treat bone-weakening osteoporosis by increasing bone mass. An estimated 10 million Americans, mostly women, have
osteoporosis. (Februari
2009)
