Goede olijfolie tegen kanker en goed voor het hart*
Uit twee Spaanse studies blijkt dat olijfolie en dan in het bijzonder de extra virgin
olijfolie goed blijkt te zijn tegen hart- en vaatziektes en tegen borstkanker. Uit de ene studie blijkt dat olijfolie ontstekingen tegengaat die kunnen leiden tot hart- en vaatziektes, diabetes en kanker. Uit de andere studie blijkt dat de antioxidanten in de vorm van complexe fenolen de overexpressie van het HER2/neu eiwit
in borstkankercellen fors kan onderdrukken, althans in het laboratorium.
A Study Reveals The Anti Inflammatory Properties Of Virgin Olive Oil
Researchers from the Hospital Universitario Reina Sofía de Córdoba (University Hospital Reina Sofía of Córdoba, Spain) have carried out a study in order to determine the influence of the micronutrients of certain fats on cardiovascular diseases, diabetes or cancer, and if their consumption might modify the inflammatory process in healthy people. To this end, they have studied the consumption in diets with different fatty composition, based on extra virgin olive oil, nuts and butter, observing that extra virgin olive oil modulate on a downward trend healthy individuals' inflammatory levels, whereas a diet rich in nuts has an intermediate effect and the diet rich in butter exerts a damaging effect on inflammation mediators.
High-impact international scientific journals specialized in the nutrition field such as the American Journal of Clinical Nutrition, Journal of Clinical Endocrinology and Metabolism or Atherosclerosis have already echoed the results of this work carried out by the Lipids and Atherosclerosis Unit of the Reina Sofía University Hospital, under the direction of doctors Francisco Pérez Jiménez and José López Miranda, with the collaboration of the Laboratory of Experimental Nephrology and Vascular Pathology of the Jiménez Díaz Foundation.
During the development of this research work, the persons in charge of the study have observed that olive oil reduces the plasmatic concentration of other molecules which express in the walls of blood vessels and also favour inflammation, confirming the incidence of consumption in the improvement of the inflammatory process. The researchers attribute this new beneficial effect of olive oil, at least in part, to the high presence of micronutrients and, despite the fact that at present we are ignorant of the effects of most of them, they have suggested possibility that they might act due to a direct effect, similar to that of anti-inflammatory drugs.
Antioxidant properties
The Lipids and Atherosclerosis Unit of the Reina Sofía Hospital is working at present in the search for beneficial effects related to the usual consumption of virgin olive oil. According to Doctor Pablo Pérez Martínez, "the main property of olive oil is its richness of antioxidants, which makes it a unique fat. Therefore, we must clarify which is the added value of its components, as that is the only way to establish that a healthy diet must contain olive oil as its main fat." According to Doctor Pérez Martínez, "olive oil is a key food in the Mediterranean diet, as it is its main source of fats and provides it with high-nutritional-value micro-components." According to the researcher, a diet based on olive oil reduces bad cholesterol (LDL) brings arterial pressure down, improves diabetes control and reduces the trend to suffer from thrombosis. In the last years, and thanks to the new technologies, we have other oils suitable for human nutrition with a similar fatty composition, such as those extracted from certain seeds with high varieties of oleic, like sunflower, soya and canola oil. However, according to Doctor Pérez Martínez, such oils present an essential difference with the oil extracted from olives, as "olive oil is a natural juice, which contains hundreds of non-fatty micro-components of biological interest, such as vitamin E, carotenes, scalene, chlorophyll and, especially, phenolic compounds".
Micronutrients benefits
According to Doctor Pérez Martínez, the results of this study confirm once again the benefits of the Mediterranean diet, "a model of feeding with a high monounsaturated fat content from virgin olive oil, able to induce a wide range of biological effects on the cardiovascular system". In addition, according to the researcher, the most recent studies are gradually defining that some benefits depend on or can be favoured with the consumption of olive oil rich in micro-components, like in the case of extra virgin olive oil and its anti-inflammatory properties, which are a new added value, together with the rest of well-known beneficial effects.
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Why extra-virgin olive oil is so good for you
Good quality extra-virgin olive oil contains health-relevant chemicals, 'phytochemicals', that can trigger cancer cell death.
New research published in the open access journal BMC Cancer sheds more light on the suspected association between olive oil-rich Mediterranean diets and reductions in breast cancer risk.
Javier Menendez from the Catalan Institute of Oncology and Antonio Segura-Carretero from the University of Granada in Spain led a team of researchers who set out to investigate which parts of olive oil were most active against cancer. Menendez said, "Our findings reveal for the first time that all the major complex phenols present in extra-virgin olive oil drastically suppress overexpression of the cancer gene HER2 in human breast cancer cells".
Extra-virgin olive oil is the oil that results from pressing olives without the use of heat or chemical treatments. It contains phytochemicals that are otherwise lost in the refining process. Menendez and colleagues separated the oil into fractions and tested these against breast cancer cells in lab experiments. All the fractions containing the major extra-virgin phytochemical polyphenols (lignans and secoiridoids) were found to effectively inhibit HER2.
Although these findings provide new insights on the mechanisms by which good quality oil, i.e. polyphenol-rich extra-virgin olive oil, might contribute to a lowering of breast cancer risk in a HER2-dependent manner, extreme caution must be applied when applying the lab results to the human situation. As the authors point out, "The active phytochemicals (i.e. lignans and secoiridoids) exhibited tumoricidal effects against cultured breast cancer cells at concentrations that are unlikely to be achieved in real life by consuming olive oil".
Nevertheless, and according to the authors, "These findings, together with the fact that that humans have safely been ingesting significant amounts of lignans and secoiridoids as long as they have been consuming olives and extra-virgin oil, strongly suggest that these polyphenols might provide an excellent and safe platform for the design of new anti breast-cancer drugs".
http://www.biomedcentral.com/bmccancer/ (Februari
2009)
