Pistache noten voor een beter cholesterol*
Uit een kleine studie onder 28 deelnemers blijkt dat iedere dag pistachenoten zorgen voor lagere bloedwaarden aan slecht
cholesterol (LDL). Na twee weken een typisch westers dieet kregen de deelnemers een vetarm dieet al dan niet aangevuld met dagelijks 1 of 2 porties pistachenoten. Na vier weken bleek dat het dieet met 1 portie (= 17) pistachenoten het LDL met 9% deed dalen. Het dieet met 2 porties deed het LDL met 12% dalen.
Effects of pistachios on cardiovascular disease risk factors and potential mechanisms of action: a dose-response study1,2,3
Sarah K Gebauer1, Sheila G West1, Colin D Kay1, Petar Alaupovic1, Deborah Bagshaw1 and Penny M Kris-Etherton1
1 From Integrative Biosciences (SKG and PMK-E) and the Departments of Nutritional Sciences (CDK, DB, and PMK-E) and Biobehavioral Health (SGW and CDK), Pennsylvania State University; Oklahoma Medical Research Foundation, (PA)
Background:Nut consumption lowers cardiovascular disease (CVD) risk. Studies are lacking about the effects of pistachios, a nutrient-dense nut, on CVD risk factors, dose-response relations, and lipid-lowering mechanisms.
Objective:We evaluated the effects of 2 doses of pistachios, added to a lower-fat diet, on lipids and lipoproteins, apolipoprotein (apo)-defined lipoprotein subclasses, and plasma fatty acids. To investigate the mechanisms of action, we measured cholesteryl ester transfer protein and indexes of plasma stearoyl-CoA desaturase activity (SCD).
Design:In a randomized crossover controlled-feeding study, 28 individuals with LDL cholesterol 2.86 mmol/L consumed 3 isoenergetic diets for 4 wk each. Baseline measures were assessed after 2 wk of a typical Western diet. The experimental diets included a lower-fat control diet with no pistachios [25% total fat; 8% saturated fatty acids (SFAs), 9% monounsaturated fatty acids (MUFAs), and 5% polyunsaturated fatty acids (PUFAs)], 1 serving/d of a pistachio diet (1 PD; 10% of energy from pistachios; 30% total fat; 8% SFAs, 12% MUFAs, and 6% PUFAs), and 2 servings/d of a pistachio diet (2 PD; 20% of energy from pistachios; 34% total fat; 8% SFAs, 15% MUFAs, and 8% PUFAs).
Results:The 2 PD decreased (P < 0.05 compared with the control diet) total cholesterol (–8%), LDL cholesterol (–11.6%), non-HDL cholesterol (–11%), apo B (–4%), apo B/apo A-I (–4%), and plasma SCD activity (–1%). The 1 PD and 2 PD, respectively, elicited a dose-dependent lowering (P < 0.05) of total cholesterol/HDL cholesterol (–1% and –8%), LDL cholesterol/HDL cholesterol (–3% and –11%), and non-HDL cholesterol/HDL cholesterol (–2% and –10%).
Conclusions:Inclusion of pistachios in a healthy diet beneficially affects CVD risk factors in a dose-dependent manner, which may reflect effects on
SCD. (Oktober
2008)
