Kruid tegen bijwerkingen medicijnen*
Uit een studie weliswaar met speciale ratten blijkt dat het kruid mariadistel effectief de bijwerkingen teniet doet van medicijnen die gebruikt wordt tegen
tuberculose. De gebruikte medicatie veroorzaakt vaak toxische reacties in de lever die tot hepatitis kunnen leiden. In de studie werden extracten gebruikt van mariadistel, silymarin genaamd. Deze extracten bleken zeer effectief en geen enkel nadelig effect te hebben.
Silymarin protects liver against toxic effects of anti-tuberculosis drugs in experimental animals
Sude Eminzade , Fikriye Uras and Fikret V. Izzettin
Nutrition & Metabolism 2008, 5:18doi:10.1186/1743-7075-5-18
Background
The first line anti-tuberculosis drugs isoniazid (INH), rifampicin (RIF) and pyrazinamide (PZA) continues to be the effective drugs in the treatment of tuberculosis, however, the use of these drugs is associated with toxic reactions in tissues, particularly in the liver, leading to hepatitis. Silymarin, a standard plant extract with strong antioxidant activity obtained from S. marianum, is known to be an effective agent for liver protection and liver regeneration. The aim of this study was to investigate the protective actions of silymarin against hepatotoxicity caused by different combinations of anti-tuberculosis drugs.
Methods
Male Wistar albino rats weighing 250-300g were used to form 6 study groups, each group consisting of 10 rats. Animals were treated with intra-peritoneal injection of isoniazid (50 mg/kg) and rifampicin (100 mg/kg); and intra-gastric administration of pyrazinamid (350 mg/kg) and silymarin (200 mg/kg). Hepatotoxicity was induced by a combination of drugs with INH+RIF and INH+RIF+PZA. Hepatoprotective effect of silymarin was investigated by co-administration of silymarin together with the drugs. Serum biochemical tests for liver functions and histopathological examination of livers were carried out to demonstrate the protection of liver against anti-tuberculosis drugs by silymarin.
Results
Treatment of rats with INH+RIF or INH+RIF+PZA induced hepatotoxicity as evidenced by biochemical measurements: serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) activities and the levels of total bilirubin were elevated, and the levels of albumin and total protein were decreased in drugs-treated animals. Histopathological changes were also observed in livers of animals that received drugs. Simultaneous administration of silymarin significantly decreased the biochemical and histological changes induced by the drugs.
Conclusion
The active components of silymarin had protective effects against hepatotoxic actions of drugs used in the chemotherapy of tuberculosis in animal models. Since no significant toxicity of silymarin is reported in human studies, this plant extract can be used as a dietary supplement by patients taking anti-tuberculosis
medications.
Meer info
over de studie. (Juli
2008)
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