Kalium tegen hartproblemen.*
Dat voeding rijk aan kalium goed is tegen schade als gevolg van hoge bloeddruk was al bekend. In deze studie, met ratten, werd vastgesteld dat extra kalium ook beschermt bij normale bloeddruk tegen de schade aan hart en bloedvaten als gevolg een
opgewekte hartaanval.
Zes weken oude ratten kregen zes weken lang een kaliumrijke of kaliumarme voeding, waarna een hartaanval opgewekt werd. De schade van de hartaanval was in de kaliumrijke groep duidelijk kleiner en hun bloedvaten waren ook duidelijk beter.
Dietary potassium supplementation improves vascular structure and ameliorates the damage caused by cerebral ischemia in normotensive rats
Christine S Rigsby , David M Pollock and Anne M Dorrance
Nutrition & Metabolism 2008, 5:3doi:10.1186/1743-7075-5-3
Abstract (provisional)
Background
Dietary potassium supplementation in hypertensive rats is cardioprotective. This protection includes a blood pressure independent reduction in the amount of damage caused by cerebral ischemia. Therefore, we hypothesized that dietary potassium supplementation would improve the outcome of ischemic stroke by improving cerebral vessel structure in normotensive rats.
Methods
Wistar Kyoto (WKY) rats were fed a high (HK) or low potassium (LK) diet for six weeks from six weeks of age. At the end of treatment, cerebral ischemia was induced by middle cerebral artery (MCA) occlusion and the resultant infarct was quantified and expressed as a percentage of the hemisphere infarcted (%HI). MCA structure was assessed in an additional group of rats using a pressurized arteriograph.
Results
The cerebral infarct was significantly smaller in rats fed the HK diet, compared to rats fed the LK diet (21+/-5.4 vs 33.5+/-4.8 %HI HK vs LK p<0.05). Vessel structure was improved in WKY rats fed the HK diet as indicated by an increase in the MCA lumen (298+/-6.3 vs 276+/-3.9 microns HK vs LK p<0.05) and outer diameters (322+/-7.6 vs 305+/-4.8 microns HK vs LK p<0.05). Wall thickness and area were unchanged, suggesting an outward euthrophic remodelling process. The HK diet had no effect on body weight or telemetry blood pressure.
Conclusions
These studies are the first to show a beneficial effect of dietary potassium in rats with normal blood
pressure.
The complete article is available as a provisional PDF. The fully formatted PDF and HTML versions are in production.
(Februari
2008)
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