Broccoli en bloemkool halveren kans op prostaatkanker*
Uit een Amerikaanse studie onder 29.000 mannen die 4 jaar lang nauwkeurig gevolgd werden blijkt dat het twee keer per week eten van
broccoli de kans op een agressieve vorm van
prostaatkanker wel met 45% kan verminderen. Het eten van
bloemkool doet die kans zelfs met 52% verminderen. Het is al lang bekend dat kruisbloemige groenten goed zijn tegen het ontstaan van kanker doch dit is de eerste studie die aantoont dat dit ook geldt voor een agressieve vorm van kanker in dit geval prostaatkanker. Agressieve vormen van prostaatkanker hebben de neiging uit te zaaien in het lichaam en door nu minstens
een keer per week kruisbloemige groenten te eten wordt de kans op een agressieve vorm veel kleiner. De verklaring hiervoor ligt volgens de onderzoekers in het feit dat kruisbloemige groenten bioactieve stoffen bevatten die ons DNA beschermen.
Prospective Study of Fruit and Vegetable Intake and Risk of Prostate Cancer
Victoria A. Kirsh, Ulrike Peters, Susan T. Mayne, Amy F. Subar, Nilanjan Chatterjee, Christine C. Johnson, Richard B. Hayes
on behalf of the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial
Affiliations for authors: Research Unit, Division of Preventive Oncology, Cancer Care Ontario, Toronto, ON, Canada (VAK); Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT (VAK, STM); Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA (UP); Department of Epidemiology, University of Washington, Seattle, WA (UP); Divisions of Cancer Epidemiology and Genetics (NC, RBH) and Cancer Control and Population Sciences (AFS), National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD; Josephine Ford Cancer Center, Henry Ford Health System, Detroit, MI (CCJ)
Correspondence to: Richard B. Hayes, PhD, EPN 8114, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 (e-mail: hayesr@mail.nih.gov).
Background: Several epidemiologic studies have reported associations between fruit and vegetable intake and reduced risk of prostate cancer, but the findings are inconsistent and data on clinically relevant advanced prostate cancer are limited.
Methods: We evaluated the association between prostate cancer risk and intake of fruits and vegetables in 1338 patients with prostate cancer among 29361 men (average follow-up = 4.2 years) in the screening arm of the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. Participants completed both a general risk factor and a 137-item food-frequency questionnaire at baseline. Cox proportional hazards models were used to estimate relative risks (RRs) and 95% confidence intervals (CIs). All statistical tests were two-sided.
Results: Vegetable and fruit consumption was not related to prostate cancer risk overall; however, risk of extraprostatic prostate cancer (stage III or IV tumors) decreased with increasing vegetable intake (RR = 0.41, 95% CI = 0.22 to 0.74, for high versus low intake; Ptrend = .01). This association was mainly explained by intake of cruciferous vegetables (RR = 0.60, 95% CI = 0.36 to 0.98, for high versus low intake; Ptrend = .02), in particular, broccoli (RR = 0.55, 95% CI = 0.34 to 0.89, for >1 serving per week versus <1 serving per month; Ptrend = .02) and cauliflower (RR = 0.48, 95% CI = 0.25 to 0.89 for >1 serving per week versus <1 serving per month; Ptrend = .03). We found some evidence that risk of aggressive prostate cancer decreased with increasing spinach consumption, but the findings were not consistently statistically significant when restricted to extraprostatic disease.
Conclusion: High intake of cruciferous vegetables, including broccoli and cauliflower, may be associated with reduced risk of aggressive prostate cancer, particularly extraprostatic disease.
(Augustus 2007)
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