Sojanoten tegen hoge bloeddruk.*
Sojanoten opnemen in het dieet geeft een duidelijk lagere bloeddruk volgens een nieuwe studie onder 60 vrouwen van middelbare leeftijd. Gedurende 8 weken kregen de vrouwen of een speciaal vastgesteld dieet (30% vet waarvan max. 7% verzadigd, 15% eiwitten en 55% koolhydraten) of hetzelfde dieet waar 25 gram eiwitten vervangen werden door een halve kop ongezouten sojanoten. Na 8 weken kregen de vrouwen 8 weken lang het andere dieet. Iedereen kreeg 2x per week vette vis en max. 200 mg cholesterol per dag. Vooraf en na iedere periode van 8 weken werden allerlei metingen verricht. Twaalf vrouwen met hoge bloeddruk (gem. 140/90) aan het begin van de studie bleken door het dieet met sojanoten een duidelijk lagere bloeddruk (gem. 127/84) te hebben en een daling van 11% van de slechte cholesterol (LDL) waarden. De vrouwen met normale bloeddruk aan het begin van de studie hadden door de sojanoten in het dieet ook een, zij het geringere daling van de bloeddruk. Aan de cholesterolwaarden veranderden niets bij deze vrouwen.
Blood
Pressure In Postmenopausal Women May Be Improved By Soy Nuts
Substituting
soy nuts for other protein sources in a healthy diet appears to lower blood
pressure in postmenopausal women, and also may reduce cholesterol levels in
women with high blood pressure, according to a report in Archives of Internal
Medicine, one of the JAMA/Archives journals.
The American Heart Association estimates that high blood pressure (hypertension)
affects approximately 50 million Americans and 1 billion individuals worldwide.
The most common-and deadly-result is coronary heart disease, according to
background information in the article. Women with high blood pressure have four
times the risk of heart disease as women with normal blood pressure.
Francine K. Welty, M.D., Ph.D., and colleagues at Beth Israel Deaconess Medical
Center, Boston, assigned 60 healthy post-menopausal women to eat two diets for
eight weeks each in random order. The first diet, the Therapeutic Lifestyle
Changes (TLC) diet, consisted of 30 percent of calories from fat (with 7 percent
or less from saturated fat), 15 percent from protein and 55 percent from
carbohydrates; 1,200 milligrams of calcium per day; two meals of fatty fish (such
as salmon or tuna) per week; and less than 200 milligrams of cholesterol per day.
The other diet had the same calorie, fat and protein content, but the women were
instructed to replace 25 grams of protein with one-half cup of unsalted soy
nuts. Blood pressure and blood samples for cholesterol testing were taken at the
beginning and end of each eight-week period.
At the beginning of the study, 12 women had high blood pressure (140/90
milligrams of mercury or higher) and 48 had normal blood pressure. "Soy nut
supplementation significantly reduced systolic [top number] and diastolic [bottom
number] blood pressure in all 12 hypertensive women and in 40 of the 48
normotensive women," the authors write. "Compared with the TLC diet
alone, the TLC diet plus soy nuts lowered systolic and diastolic blood pressure
9.9 percent and 6.8 percent, respectively, in hypertensive women and 5.2 percent
and 2.9 percent, respectively, in normotensive women."
In women with high blood pressure, the soy diet also decreased levels of
low-density lipoprotein ("bad") cholesterol by an average of 11
percent and levels of apoliprotein B (a particle that carries bad cholesterol)
by an average of 8 percent. Cholesterol levels remained the same in women with
normal blood pressure.
"A 12-millimeter of mercury decrease in systolic blood pressure for 10
years has been estimated to prevent one death for every 11 patients with stage
one hypertension treated; therefore, the average reduction of 15 milligrams of
mercury in systolic blood pressure in hypertensive women in the present study
could have significant implications for reducing cardiovascular risk and death
on a population basis," the authors write.
"This study was performed in the free-living state; therefore, dietary soy
may be a practical, safe and inexpensive modality to reduce blood pressure. If
the findings are repeated in a larger group they may have important implications
for reducing cardiovascular risk in postmenopausal women on a population
basis," they conclude.
###
(Arch Intern Med. 2007;167:1060-1067)
This study was funded by the Harvard Medical School's Center of Excellence in
Women's Health (National Institutes of Health); a contract from the Office on
Women's Health, Department of Health and Human Services; and in part by a grant
to the Beth Israel Deaconess Medical Center General Clinical Research Center
from the National Institutes of Health. Please see the article for additional
information, including other authors, author contributions and affiliations,
financial disclosures, funding and support, etc.
(Juni 2007)