Kruisbloemige groenten tegen blaaskanker.*
Uit een studie onder 700 mensen met blaaskanker en 700 gezonde mensen blijkt dat het regelmatig eten van kruisbloemige groenten de kans op blaaskanker wel tot 30% kan verminderen. Kruisbloemige groenten zijn o.m. broccoli, boerenkool, kool, bloemkool, knolraap, spruitjes, radijs, daikon en waterkers. De bioactieve stoffen, isothiocyanaten bieden de bescherming tegen blaaskanker.
Compound
Found In Cruciferous Vegetables Associated With A Decreased Risk Of Bladder
Cancer
Isothiocyanates
(ITC) are compounds found in cruciferous vegetables such as broccoli,
cauliflower, kale, turnips, collards, Brussels sprouts, cabbage, radish, turnip
and watercress.
They exert their anti-oxidant effect via down regulation of cytochrome p450
enzyme levels and induce apoptosis by activating Phase II detoxifying enzymes.
Experimental data has suggested that these compounds may protect against the
genesis of bladder cancer.
In the International Journal of Cancer, Zhao and colleagues from the
Departments of Epidemiology and Urology at the M.D. Anderson Cancer Center
report on an epidemiological study evaluating the relationship between ITC
intake and bladder cancer risk.
The cohort consisted of 697 patients with newly diagnosed bladder cancer and 708
healthy controls matched by age, sex, and race. Dietary questionnaires were
available for all patients. The dietary intake of ITCs was compared with bladder
cancer risk and with the expression of genetic polymorphisms for the arylamine
N-acetyltransferases 2 (NAT) and glutathione S-transferase genes.
Median ITC intake per day was significantly lower in bladder cancer patients
than in controls (0.23 vs. 0.33, p < 0.001). High ITC intake was associated
with 29% lower risk of bladder cancer (odds ratio = 0.71, 95% CI 0.57 to 0.89).
This anti-cancer effect was seen more commonly in men, in patients age 64 or
older, and in smokers. NAT2 slow acetylators exhibited an increased risk of
bladder cancer in Caucasians compared with rapid acetylators (OR = 1.31, 95% CI
1.02 to 1.69). The decrease in bladder cancer risk associated with ITC intake
was not associated to NAT2, GSTM1, or GSTT1 genotype expression.
This well-conducted study for the first time demonstrates that consumption of
cruciferous vegetables with a high content of isothiocyanates such as broccoli,
cauliflower, kale, turnips, collards, Brussels sprouts, cabbage, radish, turnip
and watercress may offer a protective advantage against bladder cancer. Whether
increasing ITC intake in bladder cancer patients improves treatment response and
prevents recurrence remains to be studied.
Int J Cancer. 2007;120(10):2208-13. (Juni 2007)