Tomaten en broccoli samen tegen
prostaatkanker.*
Uit een Amerikaans onderzoek blijkt dat zowel tomaten als broccoli goed zijn bij prostaatkanker. Als zowel broccoli als tomaten in de voeding gecombineerd worden zijn de resultaten nog veel beter. In dit onderzoek van 22 weken met ratten blijkt dat alleen tomaten het kankergezwel met 34% in gewicht doen afnemen, alleen broccoli doet dat met 42% doch een combinatie van tomaten en broccoli doet het gewicht van het kankergezwel met 52% afnemen. De reducties in tumorgrootte gingen samen met een afname van de verspreiding en verhoogde celdood van de kankercellen. Omgerekend voor mannen om deze resultaten te behalen moet u dagelijks een ¼ kop rauwe broccoli en 2½ kop verse tomaten. In plaats van de verse tomaten kunt u ook 1 kop tomatensaus of ½ kop tomatenpasta nemen.
Tomato-Broccoli
Combo May Protect Against Prostate Cancer
-- Broccoli and tomato --
two vegetables known to help fight cancer -- are more effective against prostate
cancer if they're eaten together as part of a daily diet than if they're eaten
alone, a new study with rats suggests.
University of Illinois
researchers fed a diet containing 10 percent broccoli powder and 10 percent
tomato powder to a group of rats that had been implanted with prostate cancer
cells. Other groups of rats received either tomato powder or broccoli powder
alone; a supplemental dose of lycopene (the red pigment in tomatoes believed to
be an anti-cancer agent); or finasteride, a drug prescribed for men with
enlarged prostates. Another group of rats was castrated.
After 22 weeks, the
researchers found that the combined tomato/broccoli diet was the most effective
at prostate tumor reduction. Of the other treatments, castration was the only
one that came close to being as effective.
"When tomatoes and
broccoli are eaten together, we see an additive effect. We think it's because
different bioactive compounds in each food work on different anti-cancer
pathways," study co-author John Erdman, a professor of food science and
human nutrition, said in a prepared statement.
"Older men with
slow-growing prostate cancer who have chosen watchful waiting over chemotherapy
and radiation should seriously consider altering their diets to included more
tomatoes and broccoli," added study co-author and doctoral candidate
Kirstie Canene-Adams.
"To get these
effects, men should consume daily 1.4 cups of raw broccoli and 2.5 cups of fresh
tomato, or 1 cup of tomato sauce, or 1/2 cup of tomato paste. I think it's very
doable for a man to eat a cup and a half of broccoli per day or to put broccoli
on a pizza with 1/2 cup of tomato paste," Canene-Adams said.
The study was published
in the Jan. 15 issue of the journal Cancer Research.
Combinations
of Tomato and Broccoli Enhance Antitumor Activity in Dunning R3327-H Prostate
Adenocarcinomas
Kirstie Canene-Adams 1, Brian L. Lindshield ,
Shihua Wang , Elizabeth H. Jeffery , Steven K. Clinton , John W. Erdman Jr.*
1 1Division of Nutritional Sciences
and Department of Food Science and Human Nutrition, University of Illinois,
Urbana, Illinois and 2Division of Hematology and Oncology, Department
of Internal Medicine, James Cancer Hospital and Solove Research Institute, The
Ohio State University, Columbus, Ohio
* To whom correspondence should be addressed.
E-mail: jwerdman@uiuc.edu
Abstract
The consumption of diets containing 5 to 10 servings of fruits and
vegetables daily is the foundation of public health recommendations for
cancer prevention, yet this concept has not been tested in
experimental models of prostate cancer. We evaluated combinations of
tomato and broccoli in the Dunning R3327-H prostate adenocarcinoma model.
Male Copenhagen rats (n = 206) were fed diets containing 10%
tomato, 10% broccoli, 5% tomato plus 5% broccoli (5:5 combination), 10%
tomato plus 10% broccoli (10:10 combination) powders, or lycopene (23
or 224 nmol/g diet) for
~22 weeks starting 1 month prior to receiving s.c. tumor
implants. We compared the effects of diet to surgical castration (2
weeks before termination) or finasteride (5 mg/kg body weight orally,
6 d/wk). Castration reduced prostate weights, tumor areas, and tumor
weight (62%, P < 0.001), whereas finasteride reduced
prostate weights (P < 0.0001), but had no effect on tumor
area or weight. Lycopene at 23 or 224 nmol/g of the diet
insignificantly reduced tumor weights by 7% or 18%, respectively,
whereas tomato reduced tumor weight by 34% (P < 0.05).
Broccoli decreased tumor weights by 42% (P < 0.01) whereas
the 10:10 combination caused a 52% decrease (P < 0.001).
Tumor growth reductions were associated with reduced proliferation
and increased apoptosis, as quantified by proliferating cell nuclear
antigen immunohistochemistry and the ApopTag assay. The combination
of tomato and broccoli was more effective at slowing tumor growth
than either tomato or broccoli alone and supports the public health
recommendations to increase the intake of a variety of plant
components. [Cancer Res 2007;67(2):836-43]
Het voledige onderzoek: http://cancerres.aacrjournals.org/cgi/rapidpdf/0008-5472.CAN-06-3462v1.pdf (Jan. 2007)