Uien
en kerrie tegen darmkanker.*
Quercetine in bijv. uien en curcumine in Kerrie helpen darmkanker te voorkomen.
Uit een kleine studie onder mensen met een aangeboren afwijking, zij vormen poliepen in de darm die uitgroeien tot kanker, blijkt dat de toediening van quercetine en curcumine gedurende zes maanden het aantal poliepen met 60% afnam en de grootte van de poliepen met 50%. De dagelijkse hoeveelheden quercetine waren 60 mg en voor curcumine 1.440 mg. Die hoeveelheid quercetine is wel uit de dagelijkse voeding te halen voor de hoeveelheid curcumine is dat iets moeilijker omdat kerriepoeder doorgaans slechts 3-5 gewichtsprocenten curcumine bevat.
Curry
May Help Prevent Colon Cancer
Chemicals in popular spice decreased polyp sizes, study finds
Chemicals found in onions and curry may
help prevent colon cancer, a Johns Hopkins University School of Medicine study
suggests.
Published in the August issue of the
journal Clinical Gastroenterology and Hepatology, the study included five
people with familial adenomatous polyposis (FAP), an inherited form of
precancerous polyps in the lower bowel. FAP is characterized by the development
of hundreds of colorectal polyps and eventual colon cancer.
For an average of six months, the patients
received three daily oral doses of 20 milligrams of quercetin (an antioxidant
found in onions) and 480 milligrams of curcumin (found in tumeric, one of the
main ingredients of curry).
The average number of polyps in the
patients declined by 60.4 percent, and the average size of the polyps decreased
by 50.9 percent, the study said.
"We believe this is the first proof of
principle that these substances have significant effects in patients with FAP,"
study leader Dr. Francis M. Giardiello, director of the division of
gastroenterology at the university, said in a prepared statement.
He
believes that curcumin is the key agent.
"The
amount of quercetin we administered was similar to what many people consume
daily; however, the amount of curcumin is many times what a person might ingest
in a typical diet, since tumeric only contains on average three percent to five
percent curcumin by weight," Giardiello said.
It's
not likely that simply eating onions and curry would provide the same benefits
seen in this study, he noted.
The
researchers plan to conduct a randomized clinical trial with more patients.
Combination Treatment With Curcumin and Quercetin of
Adenomas in Familial Adenomatous Polyposis
,
, ,
, ,
Background
& Aims:
Familialadenomatous polyposis (FAP) is an autosomal-dominant disorder
characterized by the development of hundreds of colorectal adenomas and eventual
colorectal cancer. Regression of adenomas in this syndrome occurs with the
administration of nonsteroidal anti-inflammatory drugs and cyclooxygenase-2
inhibitors, but these compounds can have considerable side effects. We evaluated
the efficacy of the combination of diet-derived nonprescription supplements
curcumin and quercetin to regress adenomas in patients with FAP. Methods:
Five FAP patients with prior colectomy (4 with retained rectum and 1 with an
ileal anal pouch) received curcumin 480 mg and quercetin 20 mg orally 3 times a
day. The number and size of polyps were assessed at baseline and after therapy.
The Wilcoxon signed-rank test was used to determine differences in the number
and size of polyps. Treatment side effects and medication compliance also were
evaluated. Results: All 5 patients had a decreased polyp number
and size from baseline after a mean of 6 months of treatment with curcumin and
quercetin. The mean percent decrease in the number and size of polyps from
baseline was 60.4% (P < .05) and 50.9% (P < .05),
respectively. Minimal adverse side effects and no laboratory abnormalities were
noted. Conclusions: The combination of curcumin and quercetin
appears to reduce the number and size of ileal and rectal adenomas in patients
with FAP without appreciable toxicity. Randomized controlled trials are needed
to validate these findings. (Augustus 2006) (Opm.
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