Omega-3 vetzuren tegen ontstekingen en botontkalking.*
Uit onderzoek naar parodontitis, waarbij ontstekingen een grote rol spelen, blijkt dat omega-3 vetzuren een belangrijk voedingsmiddel zijn tegen de ontstekingen en zelfs botontkalking. Het is vooral het derivaat van EPA, Resolvin E1, die hiervoor verantwoordelijk is.
Omega-3
Fatty Acids Protect Against Inflammation And Bone Loss
Gum disease is initiated by bacteria
populating dental plaque and may eventually result in tissue and tooth loss.
Gum disease is similar to other chronic inflammatory diseases such as
arthritis, where inflammation causes tissue damage and is responsible for
the disease. To date, the prevention of gum disease is limited to successful
oral hygiene and regular professional care. However, despite these
preventive actions, plaque control is not enough to prevent disease in
susceptible individuals with a high inflammatory response.
Researchers presenting their findings today during the 35th Annual Meeting
of the American Association for Dental Research are introducing Resolvins, a
new family of biologically active products of omega-3 fatty acids. They are
natural endogenous regulators of the inflammatory response. Since it is now
known that inflammation plays a critical role in many diseases, including
heart diseases and asthma,
experiments were carried out to test the actions of the newly described EPA
(eicosapentanoic acid)-derived Resolvin E1 (RvE1) in regulating tissue
destruction and resolving inflammation in gum disease. Experimental gum
disease characterized by tissue inflammation and bone loss was stimulated in
rabbits by the application of specific bacteria that cause human gum disease.
The results of this study showed that topical application of RvE1 in
experimental gum disease provided remarkable protection against soft tissue
and bone loss associated with gum disease (periodontitis). Analysis of these
data supports the concept that inflammation is a good therapeutic target in
the treatment of periodontal disease.
###
This is a summary of abstract #933, "RvE1 Protects from Inflammation
and Bone Loss in Experimental Periodontitis", by H. Hasturk, A.
Kantarci, N. Ebrahimi, N. Petasis, C.N. Serhan, and T.E. Van Dyke, Goldman
School of Dental Medicine, Department of Periodontology and Oral Biology,
Boston (MA) University, USA, to be presented at 11:30 a.m. on Friday, March
10, 2006, in Northern Hemisphere A-2 of the Walt Disney World Dolphin Hotel,
during the 35th Annual Meeting of the American Association for Dental
Research.
Contact: Linda Hemphill
lhemphill@iadr.org
International & American Association for Dental Research ( maart 2006)
