Granaatappel tegen darmkanker.*

Uit een studie blijkt dat bioactieve stoffen in granaatappels een belangrijke rol spelen bij het tegengaan van ontstekingen bij darmkanker en gaan ze de kankercelgroei tegen.

Pomegranate Juice, Total Pomegranate Ellagitannins, and Punicalagin Suppress Inflammatory Cell Signaling in Colon Cancer Cells

Lynn S. Adams,* Navindra P. Seeram, Bharat B. Aggarwal, Yasunari Takada, Daniel Sand, and David Heber

Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, California 90095, and Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030

This work is supported by the Center for Dietary Supplement Research: Botanicals (CDSRB) from NIH/NCCAM Grant P50AT00151.

Abstract:

Phytochemicals from fruits such as the pomegranate (Punica granatum L) may inhibit cancer cell proliferation and apoptosis through the modulation of cellular transcription factors and signaling proteins. In previous studies, pomegranate juice (PJ) and its ellagitannins inhibited proliferation and induced apoptosis in HT-29 colon cancer cells. The present study examined the effects of PJ on inflammatory cell signaling proteins in the HT-29 human colon cancer cell line. At a concentration of 50 mg/L PJ significantly suppressed TNF">-induced COX-2 protein expression by 79% (SE = 0.042), total pomegranate tannin extract (TPT) 55% (SE = 0.049), and punicalagin 48% (SE = 0.022). Additionally, PJ reduced phosphorylation of the p65 subunit and binding to the NFB response element 6.4-fold. TPT suppressed NFB binding 10-fold, punicalagin 3.6-fold, whereas ellagic acid (EA) (another pomegranate polyphenol) was ineffective. PJ also abolished TNF-induced AKT activation, needed for NFB activity. Therefore, the polyphenolic phytochemicals in the pomegranate can play an important role in the modulation of inflammatory cell signaling in colon cancer cells. J. Agric. Food Chem., 54 (3), 980 -985, 2006. 10.1021/jf052005r S0021-8561(05)02005-4 (Februari 2006)