© 2005 American Association for Cancer Research (Okt. 2005)
Vitamine D verbetert overlevingskansen bij longkanker.*
Vitamin
D Is Associated with Improved Survival in Early-Stage Non–Small Cell Lung
Cancer Patients
Wei Zhou1, Rebecca Suk1,5, Geoffrey
Liu1,5, Sohee Park2, Donna S. Neuberg2,7, John
C. Wain6, Thomas J. Lynch5, Edward Giovannucci3,4,8
and David C. Christiani1,4,5
1
Occupational Health Program, Department of Environmental Health, 2
Department of Biostatistics, Harvard School of Public Health, 3
Department of Nutrition, and 4 Department of Epidemiology, Harvard
School of Public Health; 5 Department of Medicine and 6
Thoracic Surgery Unit, Department of Surgery, Massachusetts General Hospital, 7
Department of Biostatistics and Computational Biology, Dana-Farber Cancer
Institute, 8 Channing Laboratory, Brigham and Women's Hospital,
Harvard Medical School, Boston, Massachusetts
Requests
for reprints: David C. Christiani, Occupational Health Program, Department of
Environmental Health, Harvard School of Public Health, 665 Huntington Avenue,
Boston, MA 02115. Phone: 617-432-1641; Fax: 617-432-6981. E-mail: dchris@hohp.harvard.edu
Vitamin
D may inhibit the development and progression of a wide spectrum of
cancers. We investigated the associations of surgery season and
vitamin D intake with recurrence-free survival (RFS) and overall
survival in 456 early-stage non–small cell lung cancer patients.
The data were analyzed using log-rank test and Cox proportional
hazards models. The median (range) follow-up time was 71 (0.1-140)
months, with 161 recurrence and 231 deaths. Patients who had surgery
in summer had a better RFS than those who had surgery in winter (adjusted
hazard ratio, 0.75; 95% confidence interval, 0.56-1.01), with 5-year
RFS rates of 53% (45-61%) and 40% (32-49%), respectively (P =
0.10, log-rank test). Similar association between surgery season and
RFS was found among the 321 patients with dietary information (P
= 0.33, log-rank test). There was no statistically significant
association between vitamin D intake and RFS. Because both season and
vitamin D intake are important predictors for vitamin D levels, we
investigated the joint effects of surgery season and vitamin D
intake. Patients who had surgery during summer with the highest
vitamin D intake had better RFS (adjusted hazard ratio, 0.33; 95%
confidence interval, 0.15-0.74) than patients who had surgery during
winter with the lowest vitamin D intake, with the 5-year RFS rates
of 56% (34-78%) and 23% (4-42%), respectively. Similar associations of
surgery season and vitamin D intake with overall survival were also
observed. In conclusion, the joint effects of surgery season and
recent vitamin D intake seem to be associated with the survival of
early-stage non–small cell lung cancer patients.
Cancer
Epidemiology Biomarkers & Prevention Vol. 14, 2303-2309, October 2005
© 2005 American Association for Cancer Research (Okt. 2005)
